Micronutrients, N-Acetyl Cysteine, Probiotics and Prebiotics, a Review of Effectiveness in Reducing HIV Progression

Nutrients - Tập 2 Số 6 - Trang 626-651
Ruben Hummelen1,2, Jaimie Hemsworth3, Gregor Reid1,4
1Canadian Research & Development Centre for Probiotics, Lawson Health Research Institute, 268 Grosvenor Street, N6A 4V2, London, Ontario, Canada
2Department of Public Health, Erasmus MC, University Medical Center Rotterdam, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands
3Division of Food and Nutritional Sciences at Brescia University College, The University of Western Ontario, 1285 Western Road, N6G 1H2, London, Ontario, Canada
4Departments of Microbiology & Immunology and Surgery, The University of Western Ontario, 1151 Richmond Street, N6A 3K7, London, Ontario, Canada

Tóm tắt

Low serum concentrations of micronutrients, intestinal abnormalities, and an inflammatory state have been associated with HIV progression. These may be ameliorated by micronutrients, N-acetyl cysteine, probiotics, and prebiotics. This review aims to integrate the evidence from clinical trials of these interventions on the progression of HIV. Vitamin B, C, E, and folic acid have been shown to delay the progression of HIV. Supplementation with selenium, N-acetyl cysteine, probiotics, and prebiotics has considerable potential, but the evidence needs to be further substantiated. Vitamin A, iron, and zinc have been associated with adverse effects and caution is warranted for their use.

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