Micronodular thymoma with lymphoid stroma: an immunohistochemical study of the distribution of Langerhans cells and mature dendritic cells in six patients

Histopathology - Tập 66 Số 2 - Trang 300-307 - 2015
Yoshinori Ishikawa1, Hisashi Tateyama2, Megumi Yoshida2, Koji Takami3, Haruhisa Matsuguma4, Tetsuo Taniguchi1, Noriyasu Usami1, Koji Kawaguchi1, Takayuki Fukui1, Futoshi Ishiguro1, Shota Nakamura1, Kohei Yokoi1
1Department of Thoracic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
2Department of Pathology, Clinical Laboratory, Kasugai Municipal Hospital, Kasugai, Japan
3Department of Thoracic Surgery National Hospital Organization Osaka Medical Centre Osaka Japan
4Division of Thoracic Surgery Tochigi Cancer Centre Utsunomiya Tochigi Japan

Tóm tắt

AimsMicronodular thymoma with lymphoid stroma (MNT) is an uncommon variant of thymoma, characterized by multiple small nodules consisting of type A thymoma‐like cells, which are separated by abundant B lymphocytes. The aim of the study was to elucidate the pathogenesis of the stromal lymphoid hyperplasia, which is currently unclear.Methods and resultsWe retrieved six cases of MNT, and immunohistochemically examined the number and distribution of Langerhans cells (LCs) and mature dendritic cells (DCs), and compared them with those in type A and type AB thymomas. Many LCs were present within the small tumour nests, but LCs were rarely seen in the stroma (75.5/HPF versus 6.1/HPF, P < 0.0001). In contrast, mature DCs were present mainly in the surrounding stroma rather than within the tumour nodules (63.5/HPF versus 6.0/HPF, P < 0.0001), forming clusters with mature T lymphocytes adjacent to lymphoid follicles. In large nodules, as well as in type A and type AB thymomas, a few scattered LCs and DCs were identified. All patients were still alive and well.ConclusionsOur results suggest that LCs take up tumour antigens and migrate to the stroma, where they mature and form clusters with T lymphocytes to activate them, resulting in lymphoid follicle formation. The favourable clinical behaviour may be attributable to the immune response induced by LCs.

Từ khóa


Tài liệu tham khảo

10.1080/01926230600865549

10.1097/00000478-199908000-00014

Suster S, 1997, Histology for pathologists, 687

10.1146/annurev.iy.09.040191.001415

10.1146/annurev.immunol.18.1.767

10.1007/s00441-006-0202-8

10.1002/path.1808

Pinkus GS, 1997, Fascin, a sensitive new marker for Reed‐Sternberg cells of Hodgkin's disease: evidence for a dendritic or B cell derivation?, Am. J. Pathol., 150, 543

10.3960/jslrt.49.23

10.1097/PAS.0b013e31815b212b

10.1097/JTO.0b013e31821e8cff

Marx A, 2004, World Health Organization classification of tumours. Pathology and genetics of tumours of the lung, pleura, thymus and heart, 167

10.1046/j.1365-2559.2001.01133.x

10.1084/jem.164.2.605

10.4049/jimmunol.145.9.2833

10.1002/jlb.66.2.331

10.1097/00000478-198502000-00006

10.1002/path.1711710206

10.1309/N2TW-ENRB-1N1C-DWL0

10.4049/jimmunol.160.8.3776

10.4049/jimmunol.166.1.338

10.1097/00000478-199012000-00006

10.1002/path.1018

10.1158/1078-0432.CCR-04-1448

Poppema S, 1983, In situ analysis of the mononuclear cell infiltrate in primary malignant melanoma of the skin, Clin. Exp. Immunol., 51, 77

10.1097/00000658-199707000-00001

10.1007/s00262-004-0548-2

10.1186/1479-5876-5-62

10.1097/IGC.0b013e31825401c6

Thông tin
Thông tin xuất bản

Histopathology

Tập 66 Số 2

300-307

Thông tin tác giả