Micromanaging Vascular Smooth Muscle Cell Differentiation and Phenotypic Modulation

Arteriosclerosis, Thrombosis, and Vascular Biology - Tập 31 Số 11 - Trang 2370-2377 - 2011
Brandi N. Davis‐Dusenbery1,2,3, Chuan-Xin Wu1,2,3, Akiko Hata1,2,3
1Cardiovascular Research Institute, University of California, San Francisco, CA (A.H.).
2Department of Biochemistry, Tufts University School of Medicine, Boston, MA (C.W., A.H.)
3From the Molecular Cardiology Research Institute, Tufts Medical Center, Boston, MA (B.N.D.-D., A.H.); Department of Biochemistry, Tufts University School of Medicine, Boston, MA (C.W., A.H.); Cardiovascular Research Institute, University of California, San Francisco, CA (A.H.).

Tóm tắt

The phenotype of vascular smooth muscle cells (VSMCs) is dynamically regulated in response to various stimuli. In a cellular process known as phenotype switching, VSMCs alternate between a contractile and synthetic phenotype state. Deregulation of phenotype switching is associated with vascular disorders such as atherosclerosis, restenosis after angioplasty, and pulmonary hypertension. An important role for microRNAs (miRNAs) in VSMC development and phenotype switching has recently been uncovered. Individual miRNAs are involved in promoting both contractile and synthetic VSMC phenotype. In this review, we summarize recent advances in the understanding of miRNA function in the regulation of VSMC phenotype regulation.

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Thông tin xuất bản

Arteriosclerosis, Thrombosis, and Vascular Biology

Tập 31 Số 11

2370-2377

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