Microgravity inhibits intestinal calcium absorption as shown by a stable strontium test

European Journal of Clinical Investigation - Tập 30 Số 12 - Trang 1036-1043 - 2000
Armin Zittermann1, Martina Heer2, A. Caillot‐Augusso3, Petra Rettberg2, K. Scheld1, C. Drummer2, C Alexandre3, G. Horneck2, D. Vorobiev4, Peter Stehle1
1Institut für Ernährungswissenschaft, Universität Bonn, Germany.
2DLR‐Institut für Luft‐ und Raumfahrtmedizin, Cologne, Germany,
3Laboratoire de Biologie du Tissu Ossoux, Faculte de Medicine, St. Etienne, France, 

4Institute of Biomedical Problems, Moscow, Russia

Tóm tắt

Little is known about the onset and degree of biochemical and functional alterations in calcium metabolism during microgravity.To evaluate the effect of microgravity on intestinal calcium absorption and calcium‐regulating hormones under metabolic ward conditions.Fractional calcium absorption (Fc240 in percentage of dose administered) was determined pre‐flight, in‐flight and post‐flight, by use of a stable strontium test in one cosmonaut who spent 20 days in space. Moreover, a sequence of blood samples was collected for the determination of serum parathyroid hormone (PTH), 25‐hydroxyvitamin D, calcitriol and serum C‐telopeptide (CTx, biomarker of bone resorption) levels. During all periods of data collection, calcium intake was held constant at a minimum level of 1·000 mg day−1 and a daily supplement of 16·6 µg vitamin D2 was given. Personal ultraviolet (UV) light exposure was measured during the whole mission using a biologically weighting UV dosimeter.Fc240 was markedly reduced on flight day 19 (4·4%) as compared to pre‐flight and post‐flight data (13·4% and 17·2%, respectively). Serum calcitriol levels fell from 40·6 pg mL−1 (mean pre‐flight level) to 1·3 pg mL−1 on flight day 18 and returned into the normal range after recovery. Serum CTx increased during the flight, while serum PTH and 25‐hydroxyvitamin D levels did not change significantly.Intestinal calcium absorption can be diminished after only three weeks of microgravity. Changes are associated with a severe suppression of circulating calcitriol levels, but are independent of exogenous vitamin D supply and serum PTH levels.

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Tài liệu tham khảo

Oganov VS, 1992, Bone mineral density in cosmonauts after 4.5–6 month long flights aboard orbital station Mir, Aerospace Environ Med, 26, 20

10.1016/0094-5765(79)90059-6

Caillot‐Augusseau A, 1998, Bone formation and resorption biological markers in cosmonauts during and after a 180‐day space flight (Euromir95), Clin Chem, 44, 578, 10.1093/clinchem/44.3.578

10.1152/ajpregu.1999.277.1.R1

Alexandre C, 1988, Effects of weightlessness on phospho‐calcium metabolism and its hormonal regulation in man during the 51 G Franco‐American space flight, Pathol Biol, 36, 144

Morey‐Holton E, 1988, Vitamin D metabolites and bioactive parathyroid hormone levels during Spacelab 2, Aviat Space Environ Med, 59, 1038

10.1016/s8756-3282(98)00014-3

10.1093/ajcn/43.2.299

10.1093/ajcn/46.2.324

10.1038/sj.ejcn.1600591

10.1007/BF01625342

10.1016/S0140-6736(56)91296-X

10.1210/jcem-58-1-91

10.1016/0022-4731(84)90063-3

10.1210/jc.80.3.864

10.1016/1011-1344(95)07167-3

10.1111/j.1751-1097.1992.tb04252.x

Rettberg P, 1998, Messung der UV‐Strahlenbelastung mit dem DLR‐Biofilm, Derm, 4, 180

10.1136/bmj.295.6592.231

Molteni N, 1995, Intestinal calcium absorption as shown by stable strontium test in celiac disease before and after gluten‐free diet, Am J Gastroenterol, 90, 2025

10.1210/jc.80.2.406

10.1152/ajpendo.1993.264.5.E712

10.1016/0169-6009(91)90079-F

Haug CJ, 1998, Severe deficiency of 1,25‐dihydroxyvitamin d3 in human immunodeficiency virus infection: association with immunological hyperactivity and only minor changes in calcium homeostasis, J Clin Endocrinol Metab, 83, 3832, 10.1210/jcem.83.11.5270

10.1016/s0378-5122(96)01080-8

10.1038/ki.1986.258

10.3181/00379727-200-43467

10.1007/BF02738624

Strollo F, 1998, The effect of microgravity on testicular androgen secretion, Aviat Space Environ Med, 69, 133

10.1016/S0022-3476(83)80767-7

10.1016/0002-9343(92)90682-2

10.1056/NEJM198203253061206

10.3109/00365518409083787

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Thông tin xuất bản

European Journal of Clinical Investigation

Tập 30 Số 12

1036-1043

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