Microcephalic cerebrum with hypomyelination in the pygmy mouse (pg)

International Journal of Developmental Neuroscience - Tập 10 - Trang 453-458 - 1992
Tetsuro Sugisaki1, Wesley G. Beamer2, Tetsuya Noguchi1
1Department of Physiology, Toho University School of Medicine, Ohmori-nishi, Tokyo-143, Japan
2The Jackson Laboratory, Bar Harbor, ME 04609, U.S.A.

Tóm tắt

Abstract

To determine whether somatomedin has a direct action on cerebral development instead of an indirect action of a growth hormone, we examined the central nervous system of the pygmy mouse (pg), a mutant with normal somatomedin activity. Our findings are: (A) the weights of the pg/pg cerebrum and cerebellum weighed were significantly less than those of the normal controls (pg/+), 14 and 15% less, respectively; (B) the total DNA content was reduced by 17% in the cerebrum and cerebellum of the pg/pg mouse; (C) the total RNA content was also reduced in the cerebrum and cerebellum, proportional to the reduction in DNA; (D) CNPase activity was reduced selectively in the cerebrum of the pg/pg mouse by 25%; and (E) the pg/pg mice exhibited a strikingly reduced level of activity with an indistinct diurnal periodicity. Therefore, the present findings suggest that the action of somatomedin on the pro‐liferation and maturation of glial cells might be a necessary precondition to myelin formation.


Tài liệu tham khảo

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