Các sản phẩm phân hủy tryptophan do vi khuẩn trong sức khỏe và bệnh tật

Nature Communications - Tập 9 Số 1
Henrik M. Roager1, Tine Rask Licht2
1Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, DK-1958, Frederiksberg, Denmark
2National Food Institute, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark

Tóm tắt

Tóm tắt

Bằng chứng ngày càng tăng cho thấy các chất chuyển hóa do vi khuẩn đường ruột sản xuất đóng vai trò trung gian quan trọng trong sự giao tiếp giữa vi sinh vật và vật chủ do chế độ ăn uống gây ra. Trong bài viết này, chúng tôi tổng hợp dữ liệu mới nổi cho thấy các sản phẩm phân hủy tryptophan từ vi sinh vật, kết quả từ quá trình phân giải protein, đang ảnh hưởng đến sức khỏe của vật chủ. Các chất chuyển hóa này được cho là kích hoạt hệ thống miễn dịch thông qua việc liên kết với thụ thể hydrocarbon aryl (AHR), cải thiện hàng rào biểu mô ruột, kích thích nhu động tiêu hóa cũng như sự tiết hormone đường ruột, đồng thời có tác dụng kháng viêm, chống oxy hóa hoặc độc hại trong tuần hoàn hệ thống, và có thể điều chỉnh thành phần vi sinh vật đường ruột. Do đó, các sản phẩm phân hủy tryptophan ảnh hưởng đến nhiều quá trình sinh lý và có thể đóng góp vào sự cân bằng nội môi ở ruột cũng như trong toàn thân trong sức khỏe và bệnh tật.

Từ khóa

#vi khuẩn đường ruột #phân hủy tryptophan #hệ miễn dịch #hàng rào biểu mô ruột #cân bằng nội môi

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