MicroRNA 486-3P as a stability marker in acute coronary syndrome

Bioscience Reports - Tập 36 Số 3 - 2016
Tianling Wei1, Lasse Folkersen2, Ewa Ehrenborg3, Anders Gabrielsen4
1Department of Dermatology, Bispebjerg Hospital, Bispebjerg, Denmark
2Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark
3Atherosclerosis Research Unit, Department of Medicine, Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden
4Department of Cardiology, Karolinska University Hospital, Stockholm, Sweden

Tóm tắt

Easily accessible biomarkers are needed to diagnose cardiovascular disease precisely—particularly, to distinguish between disease subtypes that are encountered in clinical practice. Per the hypothesis that plasma miRNA is valuable for this purpose, we performed complete transcriptional profiling of an miRNA discovery-set in 14 samples: three patients with ST-elevated acute myocardial infarction (STEMI) at baseline and after three months of follow-up, four with stable ischaemic heart disease (stable-IHD) and four healthy age-matched volunteers. Our aim was to determine whether we could distinguish patients with unstable plaques from stable patients following a STEMI event. After analysing miRNA profiles, we conducted a validation study comparing three-month STEMI (n=40) with stable-IHD (n=35), which confirmed that miR-486-3P differentiates patients with three-month STEMI from those with stable-IHD (P=0.019).

Từ khóa


Tài liệu tham khảo

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Bioscience Reports

Tập 36 Số 3

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