Method development and validation of potent pyrimidine derivative by UV-VIS spectrophotometer
Tóm tắt
A rapid and sensitive ultraviolet-visible (UV-VIS) spectroscopic method was developed for the estimation of pyrimidine derivative 6-Bromo-3-(6-(2,6-dichlorophenyl)-2-(morpolinomethylamino) pyrimidine4-yl) -2H-chromen-2-one (BT10M) in bulk form. Pyrimidine derivative was monitored at 275 nm with UV detection, and there is no interference of diluents at 275 nm. The method was found to be linear in the range of 50 to 150 μg/ml. The accuracy and precision were determined and validated statistically. The method was validated as a guideline. The results showed that the proposed method is suitable for the accurate, precise, and rapid determination of pyrimidine derivative.
Tài liệu tham khảo
Mohmed MS, Awad SM, Sayed IA: Synthesis of certain pyrimidine derivatives as antimicrobial agents and anti-inflammatory agents. Molecules 2010, 15: 1882–1890. 10.3390/molecules15031882
Munawar AM, Azad M, Siddiqui L: Synthesis & antimicrobial study of some quinolinyl pyrimidine derivatives. J Chin Chem Soc 2008, 55: 394–400.
Ashraf HF, Abd EIW: Synthesis, reactions and evaluation of the antimicrobial activity of some 4-(p-Halophenyl)-4H-naphthopyran, pyranopyrimidine and pyranotriazolopyrimidine derivatives. Pharmaceuticals 2012, 5: 745–757. 10.3390/ph5070745
Nofal MZ, Emans Z, Wafaa EE: Synthesis of pyrimidines and fused pyrimidines and their evaluation of antimicrobial activity. Acta Polnniae Pharmaceutica-Drug Res 2011,68(4):507–517.
Kota RK, Kompelly KK, Surampudi R, Kulkarni R: Synthesis and anti-inflammatory activity of novel pyrazolo [3,4-d] pyrimidines. J Chem Pharm Res 2011,3(4):848–853.
Gupta JK, Sharma PK, Dudhe R, Chaudhary A: Synthesis and analgesic activity of novel pyrimidine derivatives of coumarin moiety. Acta Polnniae Pharmaceutica-Drug Res 2011,68(5):785–793.
Sondhi SM, Dinodia M, Shukla R: Synthesis, anti-inflammatory and analgesic activity evaluation of some pyrimidine derivatives. Indian J Chem 2009, 49B: 273–281.
Sharma S, Sharma PK, Kumar N, Dudhe R: A review on various heterocyclic moieties and their antitubercular activity. Biomed Pharmacother 2011, 65: 244–251. 10.1016/j.biopha.2011.04.005
Al-abdullah ES: Synthesis and anticancer activity of some novel tetralin-6-yl-pyrazoline, 2-thioxopyrimidine, 2-oxopyridine, 2-thioxo-pyridine and 2-iminopyridine derivatives. Molecules 2011, 16: 3410–3419. 10.3390/molecules16043410
EL-Zahar MI, Adb El-Karim SS, Haiba ME, Khedr MA: Synthesis, antitumor activity and molecular docking study of novel benzofuran-2-yl pyrazole pyrimidine derivatives. Acta Polnniae Pharmaceutica-Drug Res 2011,68(3):357–373.
Mohamed YA, Mohamed SF, Abdullah MM: Cytotoxicity and anti-HIV evaluations of some new synthesized quinazoline and thioxopyrimidine derivatives using 4-(thiophen-2-yl)-3,4,5,6-tetrahydrobenzo[h]quinazoline-2(1H)-thione as synthon. J Chem Sci 2012,124(3):693–702. 10.1007/s12039-012-0242-4
Chaudhary A, Sharma PK, Verma PK, Kumar N, Dudhe R: Microwave assisted synthesis of novel pyrimidine derivatives and investigation of their analgesic and ulcerogenic activity. Med Chem Res 2012,21(11):3629–3645. 10.1007/s00044-011-9907-7
Chaudhary A, Verma PK, Dudhe R: Significant anti-microbial activity of novel pyrimidine derivatives. Elixir Pharmacy 2012, 45: 7956–7963.