Metformin improves healthspan and lifespan in mice

Nature Communications - Tập 4 Số 1
Alejandro Martín‐Montalvo1, Evi M. Mercken1, Sarah J. Mitchell1, Hector H. Palacios1, Patricia L. Mote2, Morten Scheibye‐Knudsen3, Ana P. Gomes4, Theresa M. Ward1, Robin K. Minor1, Marie‐José Blouin5, Matthias Schwab6, Michaël Pollak5, Yongqing Zhang7, Yinbing Yu8, Kevin G. Becker7, Vilhelm A. Bohr3, Donald K. Ingram9, David Sinclair4, Norman S. Wolf10, Stephen R. Spindler2, Michel Bernier1, Rafael de Cabo1
1Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Baltimore, 21224, Maryland, USA
2Department of Biochemistry, University of California Riverside, 3401 Watkins Drive, Riverside, 92521, California, USA
3Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Baltimore, 21224, Maryland, USA
4Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, 02115, Massachusetts, USA
5Department of Medicine and Oncology, McGill University, Montreal, H3A 2B3, Quebec, Canada
6Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart and University of Tübingen, Auerbachstrasse 112, Stuttgart, 70376, Germany
7Gene Expression and Genomics Unit, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Baltimore, 21224, Maryland, USA
8Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, Bethesda, 20892, Maryland, USA
9Nutritional Neuroscience and Aging Laboratory, Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, 70808, Louisiana, USA
10Department of Pathology, University of Washington, Seattle, 98195-7470, Washington, USA

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