Metabolism of dietary soy isoflavones to equol by human intestinal microflora – implications for health

Molecular Nutrition and Food Research - Tập 51 Số 7 - Trang 765-781 - 2007
Jian‐Ping Yuan1, Jiang‐Hai Wang, Xin Liu
1Food Engineering Research Center of State Education Ministry, College of Life Sciences, Sun Yat-Sen University, Guangzhou, People's Republic of China. [email protected]

Tóm tắt

AbstractSoy isoflavones have received considerable attention. Individuals with isoflavones‐rich diets have significantly lower occurrences of cardiovascular disease, osteoporosis, and some cancers. The clinical effectiveness of soy isoflavones may be a function of the ability to biotransform soy isoflavones to the more potent estrogenic metabolite, equol, which may enhance the actions of soy isoflavones, owing to its greater affinity for estrogen receptors, unique antiandrogenic properties, and superior antioxidant activity. However, not all individuals consuming daidzein produce equol. Only approximately one‐third to one‐half of the population is able to metabolize daidzein to equol. This high variability in equol production is presumably attributable to interindividual differences in the composition of the intestinal microflora, which may play an important role in the mechanisms of action of isoflavones. But, the specific bacterial species in the colon involved in the production of equol are yet to be discovered. Therefore, future researches are aimed at identifying the specific bacterial species and strains that are capable of converting daidzein to equol or increasing equol production.

Từ khóa


Tài liệu tham khảo

10.1126/science.285.5426.375

10.1023/A:1021210910821

10.1097/00008469-200212000-00002

10.1016/S0959-8049(00)00233-1

10.1016/S0020-7292(02)00297-7

10.1093/jn/129.3.758S

Wolters M., 2004, Soy isoflavones in the treatment of menopausal symptoms, Ernahrungs‐Umschau, 51, 440

10.1093/jn/131.10.3168

10.1002/pros.20380

10.1016/j.phytochem.2004.03.005

10.1093/ajcn/76.2.447

10.1016/S0039-128X(02)00062-4

10.1016/j.jsbmb.2006.06.020

10.1093/toxsci/kfh147

10.1002/pros.10137

10.1093/jn/132.12.3577

10.1007/s00203-003-0551-6

10.1093/jn/135.12.2786

10.1007/s00203-004-0747-4

10.1093/jn/131.4.1362S

10.1095/biolreprod.104.029512

10.1007/s002030000222

10.1093/jn/132.9.2587

10.1093/ajcn/77.6.1459

10.1016/S0014-5793(98)01101-6

10.1126/science.1110591

Wiseman H., 2004, Influence of 10 wk of soy consumption on plasma concentrations and excretion of isoflavonoids and on gut microflora metabolism in healthy adults, Am. J. Clin. Nutr., 80, 692, 10.1093/ajcn/80.3.692

10.1093/ajcn/77.2.411

10.1021/jf030681s

10.1016/S0753-3322(02)00182-8

10.1093/jn/136.5.1215

10.1093/jn/130.7.1695

10.1038/sj.ejcn.1602020

10.1016/j.jpba.2006.10.006

10.1016/S0960-0760(02)00073-0

10.1016/S0278-6915(02)00324-1

10.1007/s00203-002-0414-6

10.1016/j.toxlet.2005.02.011

10.1016/S1570-0232(02)00789-4

10.1097/01.AOG.0000124983.66521.6a

10.1093/jn/135.6.1400

10.1016/j.envres.2004.11.006

10.1124/dmd.105.004929

10.1016/j.ejca.2004.12.005

10.1093/ilar.45.4.443

10.1016/j.bmc.2003.11.035

10.1016/S0271-5317(02)00378-0

10.1207/S15327914NC3601_5

Duncan A. M., 2000, Premenopausal equol excretors show plasma hormone profiles associated with lowered risk of breast cancer, Cancer Epidemiol. Biomarkers, 9, 581

10.1093/jn/133.7.2262

10.1093/jn/136.8.2188

10.3181/00379727-217-44241

10.1016/S0960-0760(03)00259-0

Bowey E., 2004, Role of the intestine in the production of equol, J. Nutr., 134, 1236S

10.1093/jn/134.3.596

10.1177/153537020523000302

10.1016/j.jpba.2006.01.051

10.1093/jn/136.5.1347

10.1093/jjco/hyh015

Setchell K. D. R., 2004, Equol – Origins, actions, and clinical relevance of this specific soy isoflavone metabolite, J. Nutr., 134, 1235S

10.1093/ajcn/81.5.1072

10.1093/jn/131.3.740

10.1079/BJN20051565

10.1038/sj.ejcn.1602415

10.1093/jn/136.4.946

10.1263/jbb.102.247

10.1126/science.1058709

10.1128/AEM.71.1.214-219.2005

10.1111/j.1574-6968.2002.tb11081.x

10.1016/j.anaerobe.2006.10.001

10.1126/science.291.5505.881

10.1073/pnas.0504978102

10.1016/S0002-8223(95)00149-2

10.1016/j.phymed.2005.09.013

Tamura A., 2006, Supplementation of difructose anhydride III enhanced elevation of plasma equol concentrations and lowered plasma total cholesterol in isoflavone‐fed rats, Br. J. Nutr., 96, 442, 10.1079/BJN20061780

10.1021/jf035080f

10.1079/BJN20041267

10.1089/acm.2006.12.887

10.3181/00379727-217-44236

10.1093/jn/134.10.2623

10.1159/000075592

10.1016/j.jnutbio.2006.06.002

10.1006/abbi.1998.0783

10.1021/jf053112o

10.1006/abbi.1998.0951

10.1016/S0891-5849(03)00104-7

10.1074/jbc.M602803200

10.1016/j.intimp.2006.12.004

10.1016/j.brainres.2007.01.007

10.1562/2005-07-26-RA-624

10.1111/j.1751-1097.2005.tb01519.x

10.1073/pnas.0603642103

10.1207/s15327914nc5402_10

10.1016/j.ejphar.2006.05.020

10.1016/S0300-483X(02)00195-6

10.1016/S1570-0232(02)00215-5

10.1248/bpb.24.351

10.1016/S0140-6736(97)01339-1

10.1016/0022-4731(87)90200-7

10.1016/j.jsbmb.2004.01.006

10.1016/S0960-0760(02)00067-5

10.1016/j.bbcan.2006.03.001

Nettleton J. A., 2005, The effect of soy consumption on the urinary 2:16‐hydroxyestrone ratio in postmenopausal women depends on equol production status but is not influenced by probiotic consumption, J. Nutr., 135, 603, 10.1093/jn/135.3.603

10.1002/biof.5520220145

10.1016/j.metabol.2005.10.002

10.1016/j.bcp.2005.10.009

10.1095/biolreprod.106.052142

10.1095/biolreprod.103.023713

10.1002/(SICI)1097-0045(19970701)32:2<122::AID-PROS7>3.0.CO;2-O

Lephart E. D., 2005, Equol reduces prostate size and tail skin temperature in male rats, FASEB J., 19, A447

10.1002/pros.20437

10.1021/ol0620444

Thông tin
Thông tin xuất bản

Molecular Nutrition and Food Research

Tập 51 Số 7

765-781

Thông tin tác giả