Meta-analysis of intravenous lidocaine and postoperative recovery after abdominal surgery

British Journal of Surgery - Tập 95 Số 11 - Trang 1331-1338 - 2008
Emmanuel Marret1, M Rolin2, Marc Beaussier2, Francis Bonnet1
1Department of Anaesthesiology and Intensive Care, Tenon University Hospital, Assistance Publique–Hôpitaux de Paris (AP-HP), Unité Institut National de la Santé et de la Recherche Médicale U707, Paris, France
2Department of Anaesthesiology and Intensive Care, St Antoine University Hospital, AP-HP, University Pierre et Marie Curie, Paris, France

Tóm tắt

AbstractBackgroundContinuous intravenous administration of lidocaine may decrease the duration of ileus and pain after abdominal surgery.MethodsThree databases (Medline, Embase and the Cochrane Controlled Trials Register) were searched to retrieve randomized controlled trials comparing continuous intravenous lidocaine infusion during and after abdominal surgery with placebo. Study design was scored using the Oxford Quality Score based on randomization, double-blinding and follow-up. Outcome measures were duration of ileus, length of hospital stay, postoperative pain, and incidence of nausea and vomiting.ResultsEight trials were selected. A total of 161 patients received intravenous lidocaine, with 159 controls. Intravenous lidocaine administration decreased the duration of ileus (weighted mean difference (WMD) − 8·36 h; P < 0·001), length of hospital stay (WMD − 0·84 days; P = 0·002), postoperative pain intensity at 24 h after operation on a 0–100-mm visual analogue scale (WMD − 5·93 mm; P = 0·002), and the incidence of nausea and vomiting (odds ratio 0·39; P = 0·006).ConclusionContinuous intravenous administration of lidocaine during and after abdominal surgery improves patient rehabilitation and shortens hospital stay.

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Tài liệu tham khảo

Liu, 1995, Epidural anesthesia and analgesia. Their role in postoperative outcome, Anesthesiology, 82, 1474, 10.1097/00000542-199506000-00019

Wu, 2005, Efficacy of postoperative patient-controlled and continuous infusion epidural analgesia versus intravenous patient-controlled analgesia with opioids: a meta-analysis, Anesthesiology, 103, 1079, 10.1097/00000542-200511000-00023

Marret, 2007, Meta-analysis of epidural analgesia versus parenteral opioid analgesia after colorectal surgery, Br J Surg, 94, 665, 10.1002/bjs.5825

Giebler, 1997, Incidence of neurologic complications related to thoracic epidural catheterization, Anesthesiology, 86, 55, 10.1097/00000542-199701000-00009

Hollmann, 2000, Local anesthetics and the inflammatory response: a new therapeutic indication?, Anesthesiology, 93, 858, 10.1097/00000542-200009000-00038

de Clive-Lowe, 1954, Succinyldicholine and lignocaine by continuous intravenous drip: report of 1000 administrations, Anaesthesia, 9, 96, 10.1111/j.1365-2044.1954.tb01533.x

Kaba, 2007, Intravenous lidocaine infusion facilitates acute rehabilitation after laparoscopic colectomy, Anesthesiology, 106, 11, 10.1097/00000542-200701000-00007

Herroeder, 2007, Systemic lidocaine shortens length of hospital stay after colorectal surgery: a double-blinded, randomized, placebo-controlled trial, Ann Surg, 246, 192, 10.1097/SLA.0b013e31805dac11

Moher, 1999, Improving the quality of reports of meta-analyses of randomised controlled trials: the QUOROM statement. Quality of Reporting of Meta-analyses, Lancet, 354, 1896, 10.1016/S0140-6736(99)04149-5

Jadad, 1996, Assessing the quality of reports of randomized clinical trials: is blinding necessary?, Control Clin Trials, 17, 1, 10.1016/0197-2456(95)00134-4

Cassuto, 1985, Inhibition of postoperative pain by continuous low-dose intravenous infusion of lidocaine, Anesth Analg, 64, 971, 10.1213/00000539-198510000-00005

Groudine, 1998, Intravenous lidocaine speeds the return of bowel function, decreases postoperative pain, and shortens hospital stay in patients undergoing radical retropubic prostatectomy, Anesth Analg, 86, 235, 10.1213/00000539-199802000-00003

Koppert, 2004, Perioperative intravenous lidocaine has preventive effects on postoperative pain and morphine consumption after major abdominal surgery, Anesth Analg, 98, 1050, 10.1213/01.ANE.0000104582.71710.EE

Kuo, 2006, Comparison of the effects of thoracic epidural analgesia and i.v. infusion with lidocaine on cytokine response, postoperative pain and bowel function in patients undergoing colonic surgery, Br J Anaesth, 97, 640, 10.1093/bja/ael217

Rimback, 1990, Treatment of postoperative paralytic ileus by intravenous lidocaine infusion, Anesth Analg, 70, 414

Wu, 2005, The interaction effect of perioperative cotreatment with dextromethorphan and intravenous lidocaine on pain relief and recovery of bowel function after laparoscopic cholecystectomy, Anesth Analg, 100, 448, 10.1213/01.ANE.0000142551.92340.CC

Holte, 2000, Postoperative ileus: a preventable event, Br J Surg, 87, 1480, 10.1046/j.1365-2168.2000.01595.x

Wallin, 1987, Effects of lidocaine infusion on the sympathetic response to abdominal surgery, Anesth Analg, 66, 1008, 10.1213/00000539-198710000-00017

Biber, 1973, Intestinal motility increased by tetrodotoxin, lidocaine, and procaine, Experientia, 29, 551, 10.1007/BF01926658

Wood, 1972, Excitation of intestinal muscle by atropine, tetrodotoxin, and xylocaine, Am J Physiol, 222, 118, 10.1152/ajplegacy.1972.222.1.118

Bortoff, 1975, Stimulation of intestinal smooth muscle by atropine, procaine, and tetrodotoxin, Am J Physiol, 229, 1609, 10.1152/ajplegacy.1975.229.6.1609

Ready, 1999, Acute pain: lessons learned from 25 000 patients, Reg Anesth Pain Med, 24, 499

Rigg, 2002, Epidural anaesthesia and analgesia and outcome of major surgery: a randomised trial, Lancet, 359, 1276, 10.1016/S0140-6736(02)08266-1

Devor, 1992, Systemic lidocaine silences ectopic neuroma and DRG discharge without blocking nerve conduction, Pain, 48, 261, 10.1016/0304-3959(92)90067-L

Kawamata, 2006, Effects of systemic administration of lidocaine and QX-314 on hyperexcitability of spinal dorsal horn neurons after incision in the rat, Pain, 122, 68, 10.1016/j.pain.2006.01.004

Kawamata, 2002, Experimental incision-induced pain in human skin: effects of systemic lidocaine on flare formation and hyperalgesia, Pain, 100, 77, 10.1016/S0304-3959(02)00233-6

Taguchi, 2001, Selective postoperative inhibition of gastrointestinal opioid receptors, N Engl J Med, 345, 935, 10.1056/NEJMoa010564

Sinatra, 2006, Evaluation of the effect of perioperative rofecoxib treatment on pain control and clinical outcomes in patients recovering from gynecologic abdominal surgery: a randomized, double-blind, placebo-controlled clinical study, Reg Anesth Pain Med, 31, 134

Bosio, 2005, Economic impact of POI and prolonged length of stay, Semin Colon Rectal Surg, 16, 235, 10.1053/j.scrs.2006.01.012

Salvador, 2005, Clinical and economic outcomes of prolonged postoperative ileus in patients undergoing hysterectomy and hemicolectomy, Pharmacy and Therapeutics, 30, 590

Senagore, 2007, Alvimopan accelerates gastrointestinal recovery after bowel resection regardless of age, gender, race, or concomitant medication use, Surgery, 142, 478, 10.1016/j.surg.2007.07.004

Marret, 2005, Effects of nonsteroidal antiinflammatory drugs on patient-controlled analgesia morphine side effects: meta-analysis of randomized controlled trials, Anesthesiology, 102, 1249, 10.1097/00000542-200506000-00027

Hill, 2000, Cost-effectiveness of prophylactic antiemetic therapy with ondansetron, droperidol, or placebo, Anesthesiology, 92, 958, 10.1097/00000542-200004000-00012

Ness, 2000, Intravenous lidocaine inhibits visceral nociceptive reflexes and spinal neurons in the rat, Anesthesiology, 92, 1685, 10.1097/00000542-200006000-00028

LeLorier, 1997, Discrepancies between meta-analyses and subsequent large randomized, controlled trials, N Engl J Med, 337, 536, 10.1056/NEJM199708213370806

Moher, 1998, Does quality of reports of randomised trials affect estimates of intervention efficacy reported in meta-analyses?, Lancet, 352, 609, 10.1016/S0140-6736(98)01085-X