Melanoma differentiation-associated gene-7 protein physically associates with the double-stranded RNA-activated protein kinase PKR

Jiang, 1995, Subtraction hybridization identifies a novel melanoma differentiation associated gene, mda-7, modulated during human melanoma differentiation, growth and progression, Oncogene, 11, 2477 Fickenscher, 2002, The interleukin-10 family of cytokines, Trends Immunol., 23, 89, 10.1016/S1471-4906(01)02149-4 Caudell, 2002, The protein product of the tumor suppressor gene, melanoma differentiation-associated gene 7, exhibits immunostimulatory activity and is designated IL-24, J. Immunol., 168, 6041, 10.4049/jimmunol.168.12.6041 Sarkar, 2002, mda-7 (IL-24): signaling and functional roles, Biotechniques Suppl., 30, 10.2144/Oct0204 Pataer, 2002, Adenoviral transfer of the melanoma differentiation-associated gene 7 (mda7) induces apoptosis of lung cancer cells via up-regulation of the double-stranded RNA dependent protein kinase (PKR), Cancer Res., 62, 2239 Mhashilkar, 2003, MDA-7 negatively regulates the β-catenin and PI3K signaling pathways in breast and lung tumor cells, Mol. Ther., 8, 207, 10.1016/S1525-0016(03)00170-9 Pataer, 2003, Adenoviral melanoma differentiation-associated gene 7 induces apoptosis in lung cancer cells through mitochondrial permeability transition-independent cytochrome c release, J. Thoracic Cardiovasc. Surg., 125, 1328, 10.1016/S0022-5223(02)73247-9 Mhashilkar, 2001, Melanoma differentiation associated gene (mda7): a novel anti-tumor gene for cancer gene therapy, Mol. Med., 7, 271, 10.1007/BF03401847 Wang, 2002, Interleukin 24 (MDA-7/MOB-5) signals through two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2, J. Biol. Chem., 277, 7341, 10.1074/jbc.M106043200 Su, 2003, Melanoma differentiation associated gene-7, mda-7/IL-24, selectively induces growth suppression, apoptosis and radiosensitization in malignant gliomas in a p53-independent manner, Oncogene, 22, 1164, 10.1038/sj.onc.1206062 Chada, 2004, Bystander activity of Ad-mda7: MDA-7 protein kills melanoma cells via an IL-20 receptor-dependent but STAT3-independent mechanism, Mol. Ther., 10, 1085, 10.1016/j.ymthe.2004.08.020 Vorburger, 2002, Role for the double-stranded RNA activated protein kinase PKR in E2F-1-induced apoptosis, Oncogene, 21, 6278, 10.1038/sj.onc.1205761 Williams, 2001, Signal integration via PKR, Sci. STKE, 89, RE2 Barber, 2001, Host defense, viruses and apoptosis, Cell Death Differ., 8, 113, 10.1038/sj.cdd.4400823 Jagus, 1999, PKR, apoptosis and cancer, Int. J. Biochem. Cell. Biol., 31, 123, 10.1016/S1357-2725(98)00136-8 Taylor, 1999, Inhibition of the interferon-inducible protein kinase PKR by HCV E2 protein, Science, 285, 107, 10.1126/science.285.5424.107 Yin, 2003, C114 is a novel IL-11-inducible nuclear double-stranded RNA-binding protein that inhibits protein kinase R, J. Biol. Chem., 278, 22838, 10.1074/jbc.M212969200 Sieger, 2004, The tumor suppressor activity of MDA-7/IL-24 is mediated by intracellular protein expression in NSCLC cells, Mol. Ther., 9, 355, 10.1016/j.ymthe.2003.11.014 Bennett, 2004, Serine 18 phosphorylation of RAX, the PKR activator, is required for PKR activation and consequent translation inhibition, J. Biol. Chem., 279, 42687, 10.1074/jbc.M403321200 Zhang, 2004, Regulation of apoptosis proteins in cancer cells by ubiquitin, Oncogene, 23, 2009, 10.1038/sj.onc.1207373