Mechanisms of genomic instability in human cancer: Insights from studies with human papillomavirus oncoproteins

International Journal of Cancer - Tập 109 Số 2 - Trang 157-162 - 2004
Stefan Duensing1,2,3, Karl Münger4,1,3
1Karl Münger, Department of Pathology, Harvard Medical School, NRB, Room 0958c, 77 Avenue Louis Pasteur, Boston, MA 02115
2Molecular Virology Program, University of Pittsburgh Cancer Institute, Hillman Cancer Center, Pittsburgh, PA, USA
3Stefan Duensing, Molecular Virology Program, University of Pittsburgh Cancer Institute, Hillman Cancer Center, Research Pavilion Suite 1.8, 5117 Centre Avenue, Pittsburgh, PA 15213
4Department of Pathology, Harvard Medical School, Boston, MA, USA

Tóm tắt

Abstract

Genomic instability is a hallmark of most human cancers including high‐risk human papillomavirus (HPV)‐associated anogenital neoplasia. The two HPV‐encoded oncoproteins, E6 and E7, can independently induce chromosomal abnormalities. We summarize the current state of knowledge concerning HPV‐induced genomic instability and discuss its significance in the context of human carcinogenesis. © 2003 Wiley‐Liss, Inc.

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International Journal of Cancer

Tập 109 Số 2

157-162

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