Measurement of brain perfusion by volume‐localized NMR spectroscopy using inversion of arterial water spins: Accounting for transit time and cross‐relaxation

Magnetic Resonance in Medicine - Tập 25 Số 2 - Trang 362-371 - 1992
Weiguo Zhang1, Donald S. Williams1, John A. Detre2, Alan P. Koretsky3,1
1Pittsburgh NMR Center for Biomedical Research, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213
2Department of Neurology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, 19104
3Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213.

Tóm tắt

AbstractThe theoretical model for perfusion measurement by NMR using arterial labeling of endogenous water is extended to include the effects of transit time and cross‐relaxation of tissue water with macromolecules. Water magnetization in rat brain is monitored using the STEAM method to simultaneously determine the transit time, magnetization transfer rate constant, and perfusion. The results show that the transit time in rat brain is quite short, and thus its effect on perfusion measurement is small. It is also demonstrated both theoretically and experimentally that the steady‐state effects of cross‐relaxation with macromolecules on perfusion measurement are accounted for by a proper control experiment. © 1992 Academic Press, Inc.

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Thông tin xuất bản

Magnetic Resonance in Medicine

Tập 25 Số 2

362-371

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