Maturation of the hippocampal formation and amygdala in Macaca mulatta: A volumetric magnetic resonance imaging study

Hippocampus - Tập 20 Số 8 - Trang 922-935 - 2010
Christa Payne1, Christopher J. Machado2, Nancy G. Bliwise3, Jocelyne Bachevalier2
1Department of Neurobiology and Anatomy, University of Texas Health Science Center, Houston, Texas, USA.
2Department of Neurobiology and Anatomy, University of Texas Health Science Center, Houston, Texas
3Department of Psychology, Emory University, Atlanta, Georgia

Tóm tắt

Abstract

Malformations of the hippocampal formation and amygdala have been implicated in several neurodevelopmental disorders; yet relatively little is known about their normal structural development. The purpose of this study was to characterize the early developmental trajectories of the hippocampus and amygdala in the rhesus macaques (Macaca mulatta) using noninvasive MRI techniques. T1‐weighted structural scans of 22 infant and juvenile monkeys (11 male, 11 female) were obtained between 1 week and approximately 2 yrs of age. Ten animals (five males, five females) were scanned multiple times and 12 monkeys (six males, six females) were scanned once between 1 and 4 weeks of age. Both structures exhibited significant age‐related changes throughout the first 2 yrs of life that were not explained by overall brain development. The hippocampal formation increased 117.05% in males and 110.86% in females. No sex differences were evident, but the left hemisphere was significantly larger than the right. The amygdala increased 86.49% in males and 72.94% in females with males exhibiting a larger right than left amygdala. For both structures, the most substantial volumetric increases were seen within the first month, but the hippocampal formation appeared to develop more slowly than the amygdala with the rate of hippocampal maturation stabilizing around 11 months and that of amygdala maturation stabilizing around 8 months. Differences in volumetric developmental trajectories of the hippocampal formation and amygdala largely mirror differences in the timing of the functional development of these structures. The current results emphasize the importance of including early postnatal ages when assessing developmental trajectories of neuroanatomical structures and reinforces the utility of nonhuman primates in the assessment of normal developmental patterns. © 2009 Wiley‐Liss, Inc.

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Tài liệu tham khảo

10.1016/0006-8993(78)90566-8

10.1016/j.neuroscience.2005.07.001

10.1101/lm.35100

10.1002/hipo.1115

10.1016/0925-4927(91)90031-K

10.1002/(SICI)1096-9861(19960401)367:2<274::AID-CNE9>3.0.CO;2-2

10.1111/j.1749-6632.1990.tb48906.x

10.1016/0028-3932(94)90025-6

Bachevalier J, 2008, Handbook of Developmental Cognitive Neuroscience, 499

10.1002/hipo.1993.4500030723

10.1016/j.conb.2005.03.015

10.1016/S0006-3223(99)00123-7

10.1037/0735-7044.113.6.1127

10.1016/0140-6736(93)91065-T

10.1212/WNL.35.6.866

10.1016/j.ijdevneu.2004.09.006

10.1162/0898929042304741

10.1037/a0012600

10.1016/S0301-0511(00)00058-2

10.1093/cercor/6.5.726

10.1016/S0387-7604(99)00022-4

10.1212/WNL.57.2.245

10.1073/pnas.95.19.11406

10.1016/0165-3806(96)00071-5

10.1002/cne.902140210

10.1523/JNEUROSCI.08-08-02729.1988

Eckenhoff MF, 1991, A quantitative analysis of synaptogenesis in the molecular layer of the dentate gyrus in the rhesus monkey, J Neurosci, 64, 129

10.1093/cercor/4.4.344

10.1016/S0006-8993(99)02093-4

10.1002/(SICI)1096-9861(19960304)366:2<223::AID-CNE3>3.0.CO;2-7

10.1016/S0278-5846(97)00158-9

10.1038/13158

10.1016/j.mce.2006.04.016

10.1073/pnas.96.9.5263

10.1016/j.bbr.2006.09.020

10.1111/j.1365-2818.1987.tb02837.x

10.1093/brain/122.4.593

10.1001/archpsyc.62.12.1366

10.1152/jn.00968.2003

10.1212/WNL.55.4.484

10.1196/annals.1301.021

10.1523/JNEUROSCI.0292-04.2004

Kazama A, 2007, Neonatal amygdala and orbital frontal cortex lesions disrupt flexible decision‐making in adult macaques, Soc Neurosci Abstr, 33, 305.16

10.1523/JNEUROSCI.21-24-09770.2001

10.1073/pnas.96.10.5768

10.1523/JNEUROSCI.3479-08.2008

10.1159/000096222

10.1016/j.neubiorev.2006.06.001

10.1016/j.neuroimage.2007.03.053

Lewis DA, 1997, Neurodevelopment and Adult Psychopathology, 12

10.1006/exnr.1997.6777

10.1080/1029842021000022089

10.1111/1469-7610.00103

10.1111/j.1460-9568.2007.05525.x

10.1016/j.psyneuen.2008.04.012

Machado CJ, 2003, Use of MRI techniques to investigate the maturation of the nonhuman primate temporal lobes, Soc Neurosci Abstr, 29, 183.1

10.1207/S1532694207Malkova

10.1111/j.1460-9568.2006.05175.x

Mann DR, 1998, Sexual maturation in male rhesus monkeys: Importance of neonatal testosterone exposure and social rank, J Neuroendocrinol, 156, 493

10.1037/1528-3542.6.1.73

10.1016/0925-4927(93)90016-B

10.1523/JNEUROSCI.3763-03.2004

10.1002/cne.901960110

Overman WH, 2001, Handbook of Developmental Cognitive Neuroscience, 109

10.1037/0735-7044.110.6.1205

Payne C, 2009, Handbook of Developmental Social Neuroscience, 38

Payne C, 2006, The maturation of the nonhuman primate amygdala: A magnetic resonance imaging study, Soc Neurosci Abstr, 32, 718.9

Payne C, 2007, The effects of neonatal amygdala and orbital frontal lesions on the development of dyadic social interactions in infant rhesus monkeys, Soc Neurosci Abstr, 33, 748.7

10.1111/j.1528-1157.1999.tb00735.x

10.1002/cne.901960109

10.1007/s004010050401

10.1002/dev.420260304

10.1002/ajp.1350250204

10.1002/ajp.1072

10.1093/brain/124.7.1317

10.1016/S0006-8993(98)00857-9

10.1523/JNEUROSCI.1297-04.2004

10.1111/j.1945-5100.1992.tb01051.x

Seress L, 1998, Neuronal connections, cell formation and cell migration the perinatal human hippocampal dentate gyrus, Cesk Fysiol, 47, 42

10.1016/S0306-4522(01)00156-7

10.1016/j.neurobiolaging.2005.07.019

Singer JD, 2003, Applied Longitudinal Data Analysis: Modeling Change and even Occurrence, 10.1093/acprof:oso/9780195152968.001.0001

10.1016/B978-0-12-521480-3.50015-9

10.1002/hipo.20492

10.1207/s15374424jccp2202_12

Utsunomiya H, 1999, Development of the temporal lobe in infants and children: Analysis by MR‐based volumetry, Am J Neuroradiol, 20, 717

10.1212/WNL.42.9.1743

10.3109/00207458908987429

Weis S, 1990, Down syndrome: MR quantification of brain structures and comparison with normal control subjects, Am J Neuroradiol, 12, 1207

10.1530/jrf.0.0700625

Zeamer AE, 2007, The development of infant monkeys' recognition memory abilities in the absence of a functional hippocampus, Soc Neurosci Abstr, 33, 195.8

Zeamer AE, 2008, Intact object recognition memory after damage to orbital frontal areas 11 and 13 in adult macaque monkeys, Soc Neurosci Abstr, 34, 791.3

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Hippocampus

Tập 20 Số 8

922-935

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