Matrix Metalloproteinase 9 and Vascular Endothelial Growth Factor Are Essential for Osteoclast Recruitment into Developing Long Bones

Akatsu, 1992, Preparation and characterization of a mouse osteoclast-like multinucleated cell population, J. Bone Miner. Res., 7, 1297, 10.1002/jbmr.5650071109

Bergers, 2000, Gelatinase B triggers the angiogenic switch during carcinogenesis, Nat. Cell Biol., 2, 737, 10.1038/35036374

Bergman, 1963, Two improved and simplified methods for the spectrophotometric determination of hydroxyproline, Anal. Chem, 35, 1961, 10.1021/ac60205a053

Blavier, 1995, Matrix metalloproteinases are obligatory for the migration of preosteoclasts to the developing marrow cavity of primitive long bones, J. Cell Sci., 108, 3649, 10.1242/jcs.108.12.3649

Delaissé, 1985, A new synthetic inhibitor of mammalian tissue collagenase inhibits bone resorption in culture, Biochem. Biophys. Res. Commun, 133, 483, 10.1016/0006-291X(85)90932-5

Delaissé, 1993, Pro)collagenase (matrix metalloproteinase-1) is present in rodent osteoclasts and in the underlying bone-resorbing compartment, J. Cell Sci., 106, 1071, 10.1242/jcs.106.4.1071

Delaissé, 2000, Proteinases in bone resorptionobvious and less obvious roles, Clin. Chim. Acta., 291, 223, 10.1016/S0009-8981(99)00230-2

Dieudonné, 1991, Inhibiting and stimulating effects of TGF-beta 1 on osteoclastic bone resorption in fetal mouse bone organ cultures, J. Bone Miner. Res., 5, 479, 10.1002/jbmr.5650060509

Eeckhout, 1986, Direct extraction and assay of bone tissue collagenase and its relation to parathyroid-hormone-induced bone resorption, Biochem. J., 239, 793, 10.1042/bj2390793

Everts, 1998, Cysteine proteinases and matrix metalloproteinases play distinct roles in the subosteoclastic resorption zone, J. Bone Miner. Res, 13, 1420, 10.1359/jbmr.1998.13.9.1420

Everts, 1999, Functional heterogeneity of osteoclastsmatrix metalloproteinases participate in osteoclastic resorption of calvarial bone but not in resorption of long bone, FASEB J, 13, 1219, 10.1096/fasebj.13.10.1219

Faccio, 1998, Activation of alphav beta3 integrin on human osteoclast-like cells stimulates adhesion and migration in response to osteopontin, Biochem. Biophys. Res. Commun., 249, 522, 10.1006/bbrc.1998.9180

Felix, 1990, Macrophage colony stimulating factor restores in vivo bone resorption in the op/op osteopetrotic mouse, Endocrinology., 127, 2592, 10.1210/endo-127-5-2592

Fuller, 1993, Macrophage colony-stimulating factor stimulates survival and chemotactic behavior in isolated osteoclasts, J. Exp. Med., 178, 1733, 10.1084/jem.178.5.1733

Fuller, 1995, The effect of hepatocyte growth factor on the behaviour of osteoclasts, Biochem. Biophys. Res. Commun, 212, 334, 10.1006/bbrc.1995.1974

Fuller, 1995, Macrophage inflammatory protein–1 alpha and IL-8 stimulate the motility but suppress the resorption of isolated rat osteoclasts, J. Immunol, 154, 6065, 10.4049/jimmunol.154.11.6065

Gack, 1995, Expression of interstitial collagenase during skeletal development of the mouse is restricted to osteoblast-like cells and hypertrophic chondrocytes, Cell Growth Differ, 6, 759

Garlanda, 1997, Characterization of MEC 14.7, a new monoclonal antibody recognizing mouse CD34a useful reagent for identifying and characterizing blood vessels and hematopoietic precursors, Eur. J. Cell Biol., 73, 368

Gentili, 1994, Ovotransferrin and ovotransferrin receptor expression during chondrogenesis and endochondral bone formation in developing chick embryo, J. Cell Biol, 124, 579, 10.1083/jcb.124.4.579

Gerber, 1999, VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation, Nat. Med, 5, 623, 10.1038/9467

Gillet, 1977, Purification of procollagenase and collagenase by affinity chromatography on Sepharose-collagen, FEBS Lett., 74, 126, 10.1016/0014-5793(77)80768-0

Graber, 1995, Restricted infection with canine distemper virus leads to downregulation of myelin gene transcription in cultured oligodendrocytes, Acta Neuropathol., 90, 312, 10.1007/BF00296516

Gravallese, 1998, Identification of cell types responsible for bone resorption in rheumatoid arthritis and juvenile rheumatoid arthritis, Am. J. Pathol., 152, 943

Grigoriadis, 1994, c-Fosa key regulator of osteoclast-macrophage lineage determination and bone remodeling, Science., 266, 443, 10.1126/science.7939685

Hauser, 1978, Degradation of cartilage proteoglycans by a neutral proteinase secreted by rabbit bone marrow macrophages in culture, Biochem. J., 172, 275, 10.1042/bj1720275

Hill, 1994, The effects of selective inhibitors of matrix metalloproteinases (MMPs) on bone resorption and the identification of MMPs and TIMP-1 in isolated osteoclasts, J. Cell Sci, 107, 3055, 10.1242/jcs.107.11.3055

Hofbauer, 2000, The roles of osteoprotegerin and osteoprotegerin ligand in the paracrine regulation of bone resorption, J. Bone Miner. Res, 15, 2, 10.1359/jbmr.2000.15.1.2

Hofstetter, 1995, Detection of transcripts and binding sites for colony-stimulating factor-1 during bone development, Bone., 17, 145, 10.1016/S8756-3282(95)00163-8

Holmbeck, 1999, MT1-MMP-deficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnover, Cell., 99, 81, 10.1016/S0092-8674(00)80064-1

Jemtland, 1998, Heterogeneity among cells that express osteoclast associated genes in developing bone, Endocrinology., 139, 340, 10.1210/endo.139.1.5664

Jimi, 1999, Interleukin 1 induces multinucleation and bone-resorbing activity of osteoclasts in the absence of osteoblasts/stromal cells, Exp. Cell Res., 247, 84, 10.1006/excr.1998.4320

Knight, 1995, Active site titration of peptidases, Methods Enzymol, 248, 85, 10.1016/0076-6879(95)48008-0

Kobayashi, 2000, Tumor necrosis factor alpha stimulates osteoclast differentiation by a mechanism independent of the ODF/RANKL–RANK interaction, J. Exp. Med, 11991, 275, 10.1084/jem.191.2.275

Kong, 1999, OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph node organogenesis, Nature., 397, 315, 10.1038/16852

Lacey, 1998, Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation, Cell., 93, 165, 10.1016/S0092-8674(00)81569-X

Lee, 1999, Active gelatinase B is identified by histozymography in the cartilage resorption sites of developing long bones, Dev. Dyn., 215, 190, 10.1002/(SICI)1097-0177(199907)215:3<190::AID-AJA2>3.0.CO;2-B

Lefebvre, 1991, Production of gelatin-degrading matrix metalloproteinase (type IV collagenases) and inhibitors by articular chondrocytes during their differentiation by serial subcultures and under stimulation by interleukin-1 and tumor necrosis factor alpha, Biochim. Biophys. Acta., 1094, 8, 10.1016/0167-4889(91)90020-X

Mangham, 1993, Complement and the recruitment of mononuclear osteoclasts, J. Clin. Pathol., 46, 517, 10.1136/jcp.46.6.517

Nakamura, 1995, Localization of CD44, the hyaluronate receptor, on the plasma membrane of osteocytes and osteoclasts in rat tibiae, Cell. Tissue Res., 280, 225

Nakamura, 1996, Chemical and physical properties of the extracellular matrix are required for the actin ring formation in osteoclasts, J. Bone Miner. Res., 11, 1873, 10.1002/jbmr.5650111207

Nielsen, 1997, Expression of matrix-metalloproteinase-9 in vascular pericytes in human breast cancer, Lab. Invest., 77, 345

Niida, 1999, Vascular endothelial growth factor can substitute for macrophage colony-stimulating factor in the support of osteoclastic bone resorption, J. Exp. Med., 190, 293, 10.1084/jem.190.2.293

Nordahl, 1998, Chondroclasts and osteoclasts in bones of young ratscomparison of ultrastructural and functional features, Calcif. Tissue Int., 63, 401, 10.1007/s002239900548

Okada, 1995, Localization of matrix metalloproteinase 9 (92-kilodalton gelatinase/type IV collagenase = gelatinase B) in osteoclastsimplications for bone resorption, Lab. Invest., 72, 311

Raynal, 1996, Bone sialoprotein stimulates in vitro bone resorption, Endocrinology., 137, 2347, 10.1210/endo.137.6.8641185

Reponen, 1994, High expression of 92-kD type IV collagenase (gelatinase B) in the osteoclast lineage during mouse development, J. Cell Biol., 124, 1091, 10.1083/jcb.124.6.1091

Saftig, 1998, Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin K deficient mice, Proc. Natl. Acad. Sci. USA., 95, 13453, 10.1073/pnas.95.23.13453

Sasaki, 1997, Limited cleavage of extracellular matrix protein BM-40 by matrix metalloproteinases increases its affinity for collagens, J. Biol. Chem., 272, 9237, 10.1074/jbc.272.14.9237

Sato, 1997, Identification of the membrane-type matrix metalloproteinase MT1-MMP in osteoclasts, J. Cell Sci., 110, 589, 10.1242/jcs.110.5.589

Sato, 1998, The migration of purified osteoclasts through collagen is inhibited by matrix metalloproteinase inhibitors, J. Bone Miner. Res., 13, 59, 10.1359/jbmr.1998.13.1.59

Schenk, 1967, Cartilage resorption in the tibial epiphyseal plate of growing rats, J. Cell Biol., 34, 275, 10.1083/jcb.34.1.275

Scheven, 1986, Differentiation kinetics of osteoclasts in the periosteum of embryonic bones in vivo and in vitro, Anat. Rec., 214, 418, 10.1002/ar.1092140413

Senger, 1994, Adhesive properties of osteopontinregulation by a naturally occurring thrombin-cleavage in close proximity to the GRGDS cell-binding domain, Mol. Biol. Cell., 5, 565, 10.1091/mbc.5.5.565

Simonet, 1997, Osteoprotegerina novel secreted protein involved in the regulation of bone density, Cell., 89, 309, 10.1016/S0092-8674(00)80209-3

Sommer, 1996, Expression of matrix proteins during the development of mineralized tissues, Bone., 19, 371, 10.1016/S8756-3282(96)00218-9

Terai, 1999, Role of osteopontin in bone remodeling caused by mechanical stress, J. Bone Miner. Res., 14, 839, 10.1359/jbmr.1999.14.6.839

Tezuka, 1994, Identification of matrix metalloproteinase 9 in rabbit osteoclasts, J. Biol. Chem, 269, 15006, 10.1016/S0021-9258(17)36566-3

Van De Wijngaert, 1988, Role of mineralizing cartilage in osteoclast and osteoblast recruitment, Bone., 9, 81, 10.1016/8756-3282(88)90107-X

Vu, 1998, Gelatinase Bstructure, regulation and function, Matrix Metalloproteinases, 115, 10.1016/B978-012545090-4/50006-9

Vu, 1998, MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes, Cell., 93, 411, 10.1016/S0092-8674(00)81169-1

Wiktor-Jedrzejczak, 1990, Total absence of colony-stimulating factor 1 in the macrophage-deficient osteopetrotic (op/op) mouse, Proc. Natl. Acad. Sci. USA., 87, 4828, 10.1073/pnas.87.12.4828

Xuan, 1994, Recombinant GST-human osteopontin fusion protein is functional in RGD-dependent cell adhesion, J. Cell. Biochem., 54, 247, 10.1002/jcb.240540213

Yoshida, 1990, The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene, Nature., 345, 442, 10.1038/345442a0

Yu, 1999, Localization of matrix metalloproteinase 9 to the cell surface provides a mechanism for CD44-mediated tumor invasion, Genes Dev., 13, 35, 10.1101/gad.13.1.35

Yu, 2000, Cell surface-localized matrix metalloproteinase-9 prototypically activates TGF-beta and promotes tumor invasion and angiogenesis, Genes Dev., 14, 163, 10.1101/gad.14.2.163

Zheng, 1994, Gene expression of transforming growth factor-beta 1 and its type II receptor in giant cell tumors of bone. Possible involvement in osteoclast-like cell migration, Am. J. Pathol., 145, 101995