Maternal vitamin D depletion alters neurogenesis in the developing rat brain

International Journal of Developmental Neuroscience - Tập 25 Số 4 - Trang 227-232 - 2007
Xiaoying Cui1, John J. McGrath2,3, Thomas H. J. Burne4,3, Alan Mackay‐Sim4, Darryl W. Eyles3,1
1School of Biomedical Sciences, University of Queensland, Brisbane, QLD, Australia
2Department of Psychiatry, University of Queensland, Brisbane, QLD, Australia
3Queensland Centre for Mental Health Research, The Park Centre for Metal Health, Wacol, Qld, Australia
4Eskitis Institute for Cell and Molecular Therapies Griffith University, Brisbane, QLD, Australia

Tóm tắt

AbstractEvidence is accumulating that normal levels of vitamin D are important for brain development. Vitamin D acts as an anti‐proliferative agent in a wide variety of tissues and developmental vitamin D (DVD) deficiency has been shown to alter brain structure and function. The aim of this study was to investigate the effect of DVD deficiency on neuroprogenitor formation in the neonatal brain. We show that DVD deficiency increased the number of neurospheres formed in cultures from the neonatal subventricular zone. Exogenous vitamin D added to the culture medium reduced neurosphere number in control but not DVD cultures. We show the receptor for vitamin D is concentrated in the subventricular zone and is also present in cultured neurospheres prepared from this region. These results show that vitamin D can regulate cell proliferation in the developing brain. Further studies are warranted to examine the underlying mechanisms for these findings.

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Thông tin xuất bản

International Journal of Developmental Neuroscience

Tập 25 Số 4

227-232

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