Markers of Alzheimer's disease in a population attending a memory clinic

Alzheimer's & Dementia - Tập 5 - Trang 307-317 - 2009
Giovanni B. Frisoni1,2, Annapaola Prestia1, Orazio Zanetti3, Samantha Galluzzi1, Melissa Romano1, Maria Cotelli4, Massimo Gennarelli5,6, Giuliano Binetti7, Luisella Bocchio5, Barbara Paghera8, Giovanni Amicucci9, Matteo Bonetti10, Luisa Benussi7, Roberta Ghidoni7,11, Cristina Geroldi1,2
1Laboratory of Epidemiology Neuroimaging and Telemedicine, IRCCS Centro San Giovanni di Dio FBF, Brescia, Italy
2Psychogeriatric Ward, IRCCS Centro San Giovanni di Dio FBF, Brescia, Italy
3Alzheimer Unit, IRCCS Centro San Giovanni di Dio FBF, Brescia, Italy
4Laboratory of the Neuropsychology Cognitive Neuroscience Unit, IRCCS Centro San Giovanni di Dio FBF, Brescia, Italy
5Genetics Unit, IRCCS Centro San Giovanni di Dio FBF, Brescia, Italy
6Division of Biology and Genetics, Department of Biomedical Sciences and Biotechnologies, University of Brescia, Brescia, Italy
7NeuroBioGen Laboratory Memory Clinic, IRCCS Centro San Giovanni di Dio FBF, Brescia, Italy
8Nuclear Medicine Service, Spedali Civili of Brescia, Brescia, Italy
9Service of Anesthesiology, S. Orsola-Fatebenefratelli Hospital, Brescia, Italy
10Service of Neuroradiology, Istituto Clinico Città di Brescia, Brescia, Italy
11Proteomics Unit, IRCCS Centro San Giovanni di Dio FBF, Brescia, Italy

Tóm tắt

Background

New marker‐based criteria for the diagnosis of Alzheimer's disease (AD) were recently proposed. We describe their operational translation in 144 consecutive patients referred to our Memory Clinic.

Methods

Visual ratings of hippocampal atrophy and of cortical glucose hypometabolism in magnetic resonance imaging and positron emission tomography, and concentrations of total tau and Aβ1‐42 in cerebrospinal fluid were assessed in 12 patients with subjective memory complaints (SMCs) (Mini‐Mental State Examination [MMSE] score, 28.0 ± 1.1 [mean ± SD]), 37 with mild cognitive impairment (MCI) (MMSE, 25.1 ± 3.6), 55 with AD (MMSE, 21.1 ± 3.5), and 40 with non‐AD dementia (MMSE, 21.6 ± 5.5).

Results

The sensitivity for AD of each individual biomarker was higher (65% to 87%) than for MCI (18% to 50%). Each biomarker's specificity for SMC and non‐AD dementias was good to moderate (83% and 53%). Positivity for at least one marker increased the probability 38 times of belonging to the AD group (P < 0.0001).

Conclusion

The new diagnostic criteria can be operationalized in clinical routines, but longitudinal studies of MCI patients will need to assess the criteria's prognostic value.


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Alzheimer's & Dementia

Tập 5

307-317

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