Markerfreie Karyotypisierung von Chromosomen durch spektrales Imaging

BIOspektrum - Tập 23 - Trang 282-285 - 2017
Rudolf W. Kessler1,2, Edwin Ostertag2, Karsten Rebner2
1Steinbeis-Technologie-Transferzentrum Prozesskontrolle und Datenanalyse, Hochschule Reutlingen, Reutlingen, Deutschland
2Process Analysis and Technology (PA&T), Hochschule Reutlingen, Reutlingen, Deutschland

Tóm tắt

Karyotyping is currently based on staining techniques. These methods lack reproducibility, are time-consuming and require complex expert knowledge. This paper introduces a new marker-free, fully automated and reliable screening procedure for chromosomes. The method is based on multimodal, spatially resolved spectroscopy combined with multivariate data analysis and can easily be integrated into a standard light microscope.

Tài liệu tham khảo

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