Mapping prodromal psychosis: A critical review of neuroimaging studies

European Psychiatry - Tập 27 Số 3 - Trang 181-191 - 2012
Paolo Fusar‐Poli1, Philip McGuire2, Stefan Borgwardt2
1Institute of Psychiatry, Department of Psychosis Studies, London, UK.
2Institute of Psychiatry, Department of Psychosis Studies, London, United Kingdom

Tóm tắt

AbstractThe onset of schizophrenia is usually preceded by a prodromal phase characterized by functional decline and subtle prodromal symptoms, which include attenuated psychotic phenomena, cognitive deterioration and a decline in socio-occupational function. Preventive interventions during this phase are of great interest because of the impressive clinical benefits. However, available psychopathological criteria employed to define a high risk state for psychosis have low validity and specificity. Consequently there is an urgent need of reliable neurocognitive markers linked to the pathophysiological mechanisms that underlie schizophrenia. Neuroimaging techniques have rapidly developed into a powerful tool in psychiatry as they provide an unprecedented opportunity for the investigation of brain structure and function. This review shows that neuroimaging studies of the prodromal phases of psychosis have the potentials to identify core structural and functional markers of an impending risk to psychosis and to clarify the dynamic changes underlying transition to psychosis and to address significant correlations between brain structure or function and prodromal psychopathology. Additionally, neurochemical methods can address the key role played by neurotransmitters such as dopamine and glutamate during the psychosis onset. To conclude, multimodal neuroimaging may ultimately clarify the neurobiology of the prodromal phases by the integration of functional, structural and neurochemical findings.

Từ khóa


Tài liệu tham khảo

10.1016/j.biopsych.2009.10.026

10.1093/schbul/sbp113

10.1002/hbm.20834

10.1001/archgenpsychiatry.2008.514

10.1080/13803390500360554

10.1016/j.jpsychires.2010.05.012

Steel, 2002, Structural MRI of the brain in presumed carriers of genes for schizophrenia, their affected and unaffected siblings., J Neurol Neurosurg Psychiatry., 72, 455

10.1093/schbul/sbp074

10.1016/j.schres.2005.05.010

10.1176/appi.ajp.161.6.1116

10.1111/j.1476-5381.1983.tb11031.x

10.1192/bjp.191.51.s69

10.1016/j.biopsych.2006.08.009

10.1016/j.schres.2008.08.007

10.1016/j.jpsychires.2009.08.016

10.1016/j.neubiorev.2010.12.005

10.1016/j.biopsych.2005.11.013

10.1016/0304-3940(85)90414-8

10.1093/schbul/sbm158

10.1192/bjp.bp.106.033670

10.1001/archpsyc.60.6.585

10.1192/bjp.bp.107.046789

10.1001/archgenpsychiatry.2010.77

10.1001/archgenpsychiatry.2011.46

10.1016/S0920-9964(02)00167-6

10.1038/mp.2009.108

10.1016/j.neubiorev.2006.11.006

10.1176/appi.ajp.157.7.1141

10.1038/sj.mp.4001558

10.1176/appi.ajp.160.12.2181

10.1192/bjp.191.51.s13

10.1176/appi.ajp.160.1.156

10.1016/0304-3940(80)90178-0

10.1006/nimg.2002.1296

10.1001/archpsyc.58.2.148

10.1016/S0140-6736(03)12323-9

10.1016/S0920-9964(01)00163-3

10.1016/j.neubiorev.2010.01.016

10.1016/j.biopsych.2009.05.006

10.1016/j.schres.2008.11.026

10.1016/j.schres.2010.09.016

10.1016/j.biopsych.2010.08.033

10.1176/ajp.157.1.16

10.1016/j.schres.2008.07.012

10.1038/sj.mp.4001751

10.1192/bjp.187.48.s33

10.1001/archpsyc.59.11.1002

10.1097/00001756-200109170-00043

10.1016/j.eurpsy.2008.03.008

10.1056/NEJM199003223221201

Thông tin
Thông tin xuất bản

European Psychiatry

Tập 27 Số 3

181-191

Thông tin tác giả