Managing Incidental Findings in Human Subjects Research: Analysis and Recommendations

Journal of Law, Medicine and Ethics - Tập 36 Số 2 - Trang 219-248 - 2008
Susan M. Wolf1, Frances Lawrenz1, Charles A. Nelson2, Jeffrey Kahn3, Mildred K. Cho4, Ellen Wright Clayton5, Joel G. Fletcher6, Michael Georgieff1, Dale E. Hammerschmidt1, Kathy Hudson7, Judy Illes8, Vivek Kapur9, Moira A. Keane3, Barbara A. Koenig10, Bonnie S. LeRoy1, Elizabeth G. McFarland11, Jordan Paradise3, Lisa S. Parker12, Sharon F. Terry13, Brian G. Van Ness1, Benjamin S. Wilfond11
1University of Minnesota
2Harvard University
3University of Minnesota Twin Cities
4Stanford University
5Vanderbilt University
6Mayo Clinics
7Johns Hopkins University
8, University of British Columbia
9Pennsylvania State Univ#TAB#
10Mayo College of Medicine
11University of Washington
12University of Pittsburgh
13 Genetic Alliance

Tóm tắt

Researchers, institutional review boards (IRBs), participants in human subjects research, and their families face an important but largely neglected problem — how should incidental findings (IFs) be managed in human subjects research. If researchers unexpectedly stumble upon information of potential health or reproductive significance, should they seek expert evaluation, contact the participant’s physician, tell the research participant, or respond with some combination? What should consent forms and the entire consent process say about how IFs will be handled in research? What should IRBs require?

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