Malignant thymoma associated with mixed connective tissue disease: a case report

Clinical Rheumatology - Tập 25 - Trang 262-264 - 2006
Yu-Chih Lin1, Chen-Ching Wu1, Tsan-Teng Ou1, Jeng-Hsien Yen1, Hong-Wen Liu1, Wen-Chan Tsai1
1Department of Internal Medicine, Rheumatology Unit, Kaohsiung Medical University Hospital, Kaohsiung City, Taiwan (R.O.C.)

Tóm tắt

Many autoimmune diseases have been reported to be associated with malignancy. Mixed connective tissue disease (MCTD), however, has rarely been associated with malignancy. Thymoma is one of the neoplasms often reported to be related to various immunological disorders. Among the types of thymoma defined by WHO, malignant thymoma (thymoma type C) is the one least reported to be associated with autoimmune disease. Here, we report a case of malignant thymoma with concurrent MCTD, which manifested with acrosclerosis, Raynaud’s phenomenon, arthritis (synovitis), and a high titer of anti-ribonucleoprotein antibody.

Tài liệu tham khảo

Soudajian JV, Enriquez P, Silverstein MN, Pepin JM (1974) The spectrum of diseases associated with thymoma: coincidence or syndrome? Arch Intern Med 134:374–379 Burnet M (1962) Role of the thymus and related organs in immunity. Br Med J 2:808–811 Rosai J (1999) Histological typing of tumours of the thymus, 2nd edn. Springer, Berlin Heidelberg New York Levy Y, Afek A, Sherer Y et al (1998) Malignant thymoma associated with autoimmune diseases: a retrospective study and review of the literature. Semin Arthritis Rheum 28:73–79 Ritter JH, Wick MR (1999) Primary carcinomas of the thymus gland. Semin Diagn Pathol 16:18–31 Alarcon-Segovia D, Villareal M (1987) Classification and diagnostic criteria for mixed connective tissue disease. In: Ka-sukawa R, Sharp G (eds) Mixed connective tissue disease and anti-nuclear antibodies. Elsevier, Amsterdam, p 33 Pomplun S, Wotherspoon AC, Shah G, Goldstraw P, Ladas G, Nicholson AG (2002) Immunohistochemical markers in the differentiation of thymic and pulmonary neoplasms. Histopa-thology 40:152–158 Masaoka A, Monden Y, Nakahara K et al (1981) Follow-up study of thymomas with special reference to their clinical stages. Cancer 48:2485–2492 Mark A, Robert W, Susan L, Grace S, Jane C, Gordon C (1999) Long-term outcome in mixed connective tissue disease: longitudinal clinical and serologic findings. Arthritis Rheum 42:899–909 Alarcon-Segovia D, Cardiel MH (1989) Comparison between three diagnostic criteria for mixed connective tissue disease. Study of 593 patients. J Rheumatol 16:328–334 Katayama M, Tanaka I, Hosako Y, Hama N, Yamada T, Inada S, Goto M (1995) A case of mixed connective tissue disease associated with gastric cancer and cancer of the uterine cervix. Ryumachi 35:85–89 Varoczy L, Gergely L, Zeher M, Szegedi G, Illes A (2002) Malignant lymphoma-associated autoimmune diseases-a descriptive epidemiological study. Rheumatol Int 22:233–237 Okumura M, Ohta M, Tateyama H et al (2002) The World Health Organization histologic classification system reflects the oncologic behavior of thymoma: a clinical study of 273 patients. Cancer 94:624–632 Salyer WR, Eggleston J (1976) Thymoma: a clinical and pathological study of 65 cases. Cancer 37:229–249 Ben-Shahar M, Rosenblatt E, Green J, Cohen I (1987) Malignant thymoma associated with progressive systemic sclerosis. Am J Med Sci 294:262–267