Male Germ-Line Cells Are at Risk Following Direct-Injection Retroviral-Mediated Gene Transfer in Utero

Molecular Therapy - Tập 12 - Trang 754-762 - 2005
Christopher D. Porada1, Paul J. Park1, Joe Tellez1, Ferhat Ozturk1, Hudson A. Glimp1, Graça Almeida-Porada1, Esmail D. Zanjani1
1Department of Animal Biotechnology, University of Nevada at Reno, Mail Stop 202, Reno, NV 89557-0104, USA

Tài liệu tham khảo

Kelley, 2002, Gene therapy: reality or myth for the global bleeding disorders community?, Haemophilia, 8, 261, 10.1046/j.1365-2516.2002.00646.x Arruda, 2001, Lack of germ-line transmission of vector sequences following systemic administration of recombinant AAV-2 vector in males, Mol. Ther., 4, 586, 10.1006/mthe.2001.0491 Couto, 2004, Direct exposure of mouse spermatozoa to very high concentrations of a serotype-2 adeno-associated virus gene therapy vector fails to lead to germ cell transduction, Hum. Gene Ther., 15, 287, 10.1089/104303404322886138 Ye, 1998, Evaluating the potential of germ line transmission after intravenous administration of recombinant adenovirus in the C3H mouse, Hum. Gene Ther., 9, 2135, 10.1089/hum.1998.9.14-2135 Nagano, 2002, Lentiviral vector transduction of male germ line stem cells in mice, FEBS Lett., 524, 111, 10.1016/S0014-5793(02)03010-7 Nagano, 2001, Transgenic mice produced by retroviral transduction of male germ-line stem cells, Proc. Natl. Acad. Sci. USA, 98, 13090, 10.1073/pnas.231473498 Nagano, 2000, Retrovirus-mediated gene delivery into male germ line stem cells, FEBS Lett., 475, 7, 10.1016/S0014-5793(00)01606-9 Hamra, 2002, Production of transgenic rats by lentiviral transduction of male germ-line stem cells, Proc. Natl. Acad. Sci. USA, 99, 14931, 10.1073/pnas.222561399 Huang, 2000, In vivo transfection of testicular germ cells and transgenesis by using the mitochondrially localized jellyfish fluorescent protein gene, FEBS Lett., 487, 248, 10.1016/S0014-5793(00)02271-7 Porada, 1998, In utero gene therapy: transfer and long-term expression of the bacterial neo(r) gene in sheep after direct injection of retroviral vectors into preimmune fetuses, Hum. Gene Ther., 9, 1571, 10.1089/hum.1998.9.11-1571 Tran, 2000, In utero transfer and expression of exogenous genes in sheep, Exp. Hematol., 28, 17, 10.1016/S0301-472X(99)00133-2 Cornetta, 1991, Safety issues related to retroviral-mediated gene transfer in humans, Hum. Gene Ther., 2, 5, 10.1089/hum.1991.2.1-5 Zanjani, 1992, Engraftment and long-term expression of human fetal hemopoietic stem cells in sheep following transplantation in utero, J. Clin. Invest., 89, 1178, 10.1172/JCI115701 Zanjani, 1995, Retention of long-term repopulating ability of xenogeneic transplanted purified adult human bone marrow hematopoietic stem cells in sheep, J. Lab. Clin. Med., 126, 24 Porada, 2005, Gestational age of recipient determines pattern and level of transgene expression following in utero retroviral gene transfer, Mol. Ther., 11, 284, 10.1016/j.ymthe.2004.09.009 Foote, 1980, Artificial insemination Nicopoullos, 2004, The effect of human immunodeficiency virus on sperm parameters and the outcome of intrauterine insemination following sperm washing, Hum. Reprod., 19, 2289, 10.1093/humrep/deh426 Kiessling, 1999, HIV-1 in semen: risks for transmission, disease progression, and reproduction, PRN Notebook, 4, 9 Ball, 1999, HIV-1 in semen: determination of proviral and viral titres compared to blood, and quantification of semen leukocyte populations, J. Med. Virol., 59, 356, 10.1002/(SICI)1096-9071(199911)59:3<356::AID-JMV16>3.0.CO;2-Z Dulioust, 1998, Detection of HIV-1 in seminal plasma and seminal cells of HIV-1 seropositive men, J. Reprod. Immunol., 41, 27, 10.1016/S0165-0378(98)00047-3 Petrunkina, 2000, Only low levels of spermadhesin AWN are detectable on the surface of live ejaculated boar spermatozoa, Reprod. Fertil. Dev., 12, 361, 10.1071/RD00117 Ferrara, 1997, Automation of human sperm cell analysis by flow cytometry, Clin. Chem., 43, 801, 10.1093/clinchem/43.5.801 Ikawa, 2002, Restoration of spermatogenesis by lentiviral gene transfer: offspring from infertile mice, Proc. Natl. Acad. Sci. USA, 99, 7524, 10.1073/pnas.072207299 Huntsberger, N (1981). Testicular Development in the Fetal Sheep. Univ. of Nevada, Reno, [Master's thesis]. Tokuyama, 2003, Immunostaining of stage-specific embryonic antigen-4 in intratubular germ cell neoplasia unclassified and in testicular germ-cell tumors, Oncol. Rep., 10, 1097 Shamblott, 1998, Derivation of pluripotent stem cells from cultured human primordial germ cells, Proc. Natl. Acad. Sci. USA, 95, 13726, 10.1073/pnas.95.23.13726 Kazazian, 1999, An estimated frequency of endogenous insertional mutations in humans, Nat. Genet., 22, 130, 10.1038/9638 Coutelle, 2003, The hopes and fears of in utero gene therapy for genetic disease—a review, Placenta, 24, S114, 10.1016/S0143-4004(03)00140-1 Kurita, 2004, Transgenic zebrafish produced by retroviral infection of in vitro cultured sperm, Proc. Natl. Acad. Sci. USA, 101, 1263, 10.1073/pnas.0304265101