Magnetic brain stimulation: Central motor conduction studies in multiple sclerosis

Annals of Neurology - Tập 22 Số 6 - Trang 744-752 - 1987
Christian Heß1, Kerry Mills1, N.M.F. Murray1, T.N. Schriefer1
1Department of Clinical Neurophysiology, The National Hospital, London, United Kingdom

Tóm tắt

AbstractCentral motor conduction (CMC) was evaluated in 32 normal subjects and 83 patients with multiple sclerosis, and the findings were correlated with clinical signs and evoked potential data. CMC time was obtained from the latency difference in responses from the abductor muscle of the little finger to magnetic stimulation of the motor cortex and electrical stimulation at the C‐7/T‐1 interspace. Mean CMC time in normal subjects was 6.2 msec (SD 0.86 msec), and amplitudes of responses to cortical stimuli were at least 18% of those obtained with stimuli at the wrist. CMC was abnormal in 60 patients with multiple sclerosis (72%); this correlated well with brisk finger flexor jerks (p < 0.005). CMC was abnormal in 79% of patients with weakness of the abductor muscle of the little finger and in 54% with a normal muscle. Neurological examination was normal in 7 arms with abnormal CMC. Visual evoked potentials were abnormal in 67%, somatosensory evoked potentials in 59%, and brainstem auditory evoked potentials in 39% of those tested. For each procedure more subjects had abnormal CMC and normal evoked potentials than the reverse. The technique is of value for demonstrating and documenting central motor pathway lesions in multiple sclerosis, especially when physical signs are equivocal.

Từ khóa


Tài liệu tham khảo

10.1016/S0140-6736(85)92413-4

10.1016/S0140-6736(86)91243-2

10.1016/S0140-6736(86)90050-4

10.1038/285227a0

Marsden CD, 1982, Percutaneous stimulation of spinal cord and brain: pyramidal tract conduction velocities in man, J Physiol, 328, 6P

10.1113/jphysiol.1954.sp005157

10.1113/jphysiol.1982.sp014461

10.1002/mus.880090202

10.1016/0013-4694(86)90145-8

Merton PA, 1982, Scope of a technique for electrical stimulation of human brain, spinal cord and muscle, Lancet, 2, 596

10.1136/jnnp.48.11.1135

10.1016/0013-4694(85)91094-6

10.1016/S0140-6736(84)92683-7

10.1038/310407a0

10.1002/ana.410180514

Rossini PM, 1985, Evoked potentials. Neurophysiological and clinical aspects, 115

10.1136/jnnp.50.2.159

Barker AT, 1985, Magnetic stimulation of the human brain, J Physiol, 369, 3P

10.1007/BF02441362

10.1113/jphysiol.1987.sp016621

Hess CW, 1987, Evoked potentials III

Hess CW, 1986, Magnetic stimulation of the human brain: the effects of voluntary muscle activity, J Physiol, 378, 37P

10.1002/ana.410130302

McAlpine D, 1972, Multiple sclerosis: a reappraisal, 202

10.1212/WNL.26.6_Part_2.20

Halliday AM, 1982, Evoked potentials in clinical testing

Day BL, 1986, Multiple firing of spinal motoneurons produced by single anodal electrical shocks to human motor cortex, J Physiol, 381, 45P

10.1016/0304-3940(86)90565-3

10.1212/WNL.24.6.539

Chiappa KH, 1983, Evoked potentials in clinical medicine, 72

10.1002/ana.410180515

Day BL, 1986, Differences between electrical and magnetic stimulation of the human brian, J Physiol, 378, 36P

Hess CW, 1986, Percutaneous stimulation of the human brain: a comparison of electrical and magnetic stimuli, J Physiol, 378, 35P

10.1152/jn.1954.17.4.345

Phillips CG, 1986, Movements of the hand

10.1007/BF00234417

10.1093/brain/91.1.1

10.1016/0014-4886(69)90128-9

10.1136/jnnp.49.8.954

Hess CW, 1987, Magnetic stimulation of the human brain during natural sleep, J Physiol, 388, 48P

10.1212/WNL.31.10.1229

Thông tin
Thông tin xuất bản

Annals of Neurology

Tập 22 Số 6

744-752

Thông tin tác giả