Macrocephaly, Corpus Callosum Morphology, and Autism

Journal of Child Neurology - Tập 20 Số 1 - Trang 34-41 - 2005
Sara A. Rice1, Erin D. Bigler2,3, Howard B. Cleavinger1, David F. Tate4,5, Jamie Sayer1, William McMahon6, Sally Ozonoff7, Jeff Zhiqiang Lu6, Janet E. Lainhart6
1Departments of Psychology and Neuroscience, Brigham Young University, Provo, UT
2Departments of Psychology and Neuroscience, Brigham Young University, Provo, UT, Departments of Psychiatry and Radiology, University of Utah, Salt Lake City, UT
3University of Utah
4Brown University
5Departments of Psychology and Neuroscience, Brigham Young University, Provo, UT, Brown University Training Consortium, Providence, RI
6Departments of Psychiatry and Radiology, University of Utah, Salt Lake City, UT
7The M.I.N.D. Institute, University of California, Davis, Sacramento, CA

Tóm tắt

Although the cause of autism is undetermined, a general consensus has been that some type of early aberrant neural development underlies the disorder. Given the increased prevalence of macrocephaly in autism, one theory of abnormal neural development implicates early brain growth resulting in larger brain and head size in autism. Surface area measurements of the midsagittal section of the corpus callosum can be used as an index of neural development and white-matter integrity because the corpus callosum is the major white-matter structure that interconnects the two cerebral hemispheres. The purpose of this study was to obtain corpus callosum surface area, shape, and contour in a sample of non—mentally retarded autistic subjects with macrocephaly ( n = 12) and compare them with those of matched ( n = 8), typically developing control subjects with benign macrocephaly. No significant differences were found in surface area, shape, or contour between groups, nor did corpus callosum surface area relate to measures of IQ or picture vocabulary. These findings suggest no unique difference in overall regional corpus callosum surface area in autism with macrocephaly. ( J Child Neurol 2005;20:34—41).

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Tài liệu tham khảo

10.1001/jama.289.1.49

10.1056/NEJMp020062

10.1002/ana.410430106

Minshew NJ, Sweeney JA, Bauman M.: Neurological aspects of autism, in Cohen DJ , Volkmar FR (eds): Handbook of Autism and Pervasive Developmental Disorders. New York, Wiley, 1997, 344—369.

10.1111/j.1469-7610.1996.tb01381.x

10.1212/WNL.52.5.911

10.1097/00004583-199702000-00019

10.1001/jama.290.3.393

10.1001/jama.290.3.337

10.1023/A:1005412111706

10.1177/088307380101600607

10.1212/WNL.57.2.245

10.1212/WNL.52.5.1057

10.1212/WNL.59.2.184

Farkas LG, Hreczko TA, Katie MJ: Craniofacial norms in North American Caucasians from birth to young adulthood , in Farkas LG (ed): Anthropometry of the Head and Face. New York, Raven Press, 1994, 241—335, Appendix A.

10.1023/A:1023036509476

Kanner L., 1943, Nervous Child, 2, 217

Barkovich A., 1988, AJNR Am J Neuroradiol, 9, 487

Barkovich J., 1996, AJNR Am J Neuroradiol, 17, 1643

10.1148/radiology.172.1.2740500

10.1177/088307389000500211

10.1212/WNL.57.2.235

10.1177/088307380201700302

10.1007/BF00593965

10.1097/00001756-199506090-00006

10.1001/archneur.1995.00540320070014

10.1212/WNL.55.7.1033

10.1176/ajp.154.8.1051

10.1176/jnp.11.4.470

10.1212/WNL.45.2.317

10.1177/088307380001500802

Courchesne E., 1993, AJNR Am J Neuroradiol, 160, 387

10.1093/brain/121.5.889

Rice S., 2002, J Int Neuropsychol Soc, 8, 519

10.1037/0894-4105.10.3.408

10.1093/brain/112.3.799

10.1016/0006-8993(91)91284-8

Talairach J. , Tournoux P.: Co-Planer Stereotaxic Atlas of the Human Brain: 3-Dimensional Proportional System: An Approach to Cerebral Imaging . Stuttgart, Germany, Thieme Medical Publishing, 1988.

Carpenter M., 1983, Neuroanatomy, 8

Wechsler D., 1997, Wechsler Adult Intelligence Scale-Third Edition (WAIS-III)

Wechsler D., 1991, Wechsler Intelligence Scale for Children-Third Edition (WISC-III)

Dunn LM, 1997, Peabody Picture Vocabulary Test

10.1038/nrn1009

10.1176/ajp.152.8.1145

10.1097/00001756-199906030-00005

10.1212/WNL.59.2.175

Szatmari P., 1999, J Psychiatry Neurosci, 24, 159

Bigler ED, 2003, AJNR Am J Neuroradiol, 24, 2066

10.1007/BF02172145

10.1023/A:1005592401947

American Psychiatric Association, 1994, Diagnostic and Statistical Manual of Mental Disorders: DSM-IVTM, 4

10.1111/1469-7610.00528

Rasband W., 1995, J Microbeam Anal, 4, 137

MEDx. Sterling, VA, Sensory Systems Inc., 2001.

10.3758/BF03195419

10.1002/ana.410430613

Engstrom I., 2003, Autism, 7, 99

10.1093/brain/awg110

10.1016/S0959-4388(97)80093-1

10.1001/archpsyc.59.10.885

10.1002/hbm.10102

10.1007/s00234-002-0925-5

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Journal of Child Neurology

Tập 20 Số 1

34-41

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