M2-like, dermal macrophages are maintained via IL-4/CCL24–mediated cooperative interaction with eosinophils in cutaneous leishmaniasis

Science immunology - Tập 5 Số 46 - 2020
Sang Hun Lee1, Mariana M. Chaves1, Olena Kamenyeva2, Pedro Henrique Gazzinelli-Guimarães1, Byunghyun Kang3, Gabriela Pessenda4,1, Katiuska Passelli5, Fabienne Tacchini‐Cottier5, Juraj Kabát2, Elizabeth A. Jacobsen6, Thomas B. Nutman1, David L. Sacks1
1Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
2Biological Imaging Section, Research Technology Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
3Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
4Department of Biochemistry and Immunology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, 14049-900, Brazil
5Department of Biochemistry and World Health Organization Immunology Research and Training Collaborative Center, University of Lausanne, chemin des Boveresses 155, 1066 Epalinges, Switzerland.
6Mayo Clinic Scottsdale, SC Johnson Medical Research Center, 13400 East Shea Boulevard, Scottsdale, AZ 85259, USA.

Tóm tắt

IL-4/CCL24–mediated interaction with eosinophils maintains dermis-resident macrophages as replicative niches for Leishmania major .

Từ khóa


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