Lysosomal acid lipase and lipid metabolism: new mechanisms, new questions, and new therapies
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Dubland, 2015, Lysosomal acid lipase: at the crossroads of normal and atherogenic cholesterol metabolism, Frontiers in cell and developmental biology, 3, 3, 10.3389/fcell.2015.00003
Du, 1998, Targeted disruption of the mouse lysosomal acid lipase gene: long-term survival with massive cholesteryl ester and triglyceride storage, Hum Mol Genet, 7, 1347, 10.1093/hmg/7.9.1347
Bernstein, 2013, Cholesteryl ester storage disease: review of the findings in 135 reported patients with an underdiagnosed disease, J Hepatol, 58, 1230, 10.1016/j.jhep.2013.02.014
Valayannopoulos, 2017, Lysosomal acid lipase deficiency: expanding differential diagnosis, Mol Genet Metab, 120, 62, 10.1016/j.ymgme.2016.11.002
Huang, 2014, Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages, Nat Immunol, 15, 846, 10.1038/ni.2956
O'Sullivan, 2014, Memory CD8(+) T cells use cell-intrinsic lipolysis to support the metabolic programming necessary for development, Immunity, 41, 75, 10.1016/j.immuni.2014.06.005
Schlager, 2017, Lysosomal lipid hydrolysis provides substrates for lipid mediator synthesis in murine macrophages, Oncotarget, 8, 40037, 10.18632/oncotarget.16673
Radovic, 2016, Lysosomal acid lipase regulates VLDL synthesis and insulin sensitivity in mice, Diabetologia, 59, 1743, 10.1007/s00125-016-3968-6
Ouimet, 2011, Autophagy regulates cholesterol efflux from macrophage foam cells via lysosomal acid lipase, Cell Metab, 13, 655, 10.1016/j.cmet.2011.03.023
Jerome, 2008, Lysosomal cholesterol accumulation inhibits subsequent hydrolysis of lipoprotein cholesteryl ester, Microsc Microanal, 14, 138, 10.1017/S1431927608080069
Grijalva, 2016, Autophagy is dispensable for macrophage-mediated lipid homeostasis in adipose tissue, Diabetes, 65, 967, 10.2337/db15-1219
Haka, 2009, Macrophages create an acidic extracellular hydrolytic compartment to digest aggregated lipoproteins, Molecular biology of the cell, 20, 4932, 10.1091/mbc.e09-07-0559
Haka, 2015, Monocyte-derived dendritic cells upregulate extracellular catabolism of aggregated low-density lipoprotein on maturation, leading to foam cell formation, Arterioscler Thromb Vasc Biol, 35, 2092, 10.1161/ATVBAHA.115.305843
Singh, 2016, Degradation of aggregated LDL occurs in complex extracellular sub-compartments of the lysosomal synapse, J Cell Sci, 129, 1072, 10.1242/jcs.181743
Leake, 1997, Does an acidic pH explain why low density lipoprotein is oxidised in atherosclerotic lesions?, Atherosclerosis, 129, 149, 10.1016/S0021-9150(96)06035-2
Silver, 1988, Microelectrode studies on the acid microenvironment beneath adherent macrophages and osteoclasts, Exp Cell Res, 175, 266, 10.1016/0014-4827(88)90191-7
Naghavi, 2002, pH Heterogeneity of human and rabbit atherosclerotic plaques; a new insight into detection of vulnerable plaque, Atherosclerosis, 164, 27, 10.1016/S0021-9150(02)00018-7
Hakala, 2003, Lysosomal enzymes are released from cultured human macrophages, hydrolyze LDL in vitro, and are present extracellularly in human atherosclerotic lesions, Arterioscler Thromb Vasc Biol, 23, 1430, 10.1161/01.ATV.0000077207.49221.06
Du, 2001, Lysosomal acid lipase-deficient mice: depletion of white and brown fat, severe hepatosplenomegaly, and shortened life span, J Lipid Res, 42, 489, 10.1016/S0022-2275(20)31157-3
Zhang, 2017, CRISPR/Cas9-mediated gene editing in human iPSC-derived macrophage reveals lysosomal acid lipase function in human macrophages: brief report, Arterioscler Thromb Vasc Biol, 37, 2156, 10.1161/ATVBAHA.117.310023
Jerome, 2006, Advanced atherosclerotic foam cell formation has features of an acquired lysosomal storage disorder, Rejuvenation Res, 9, 245, 10.1089/rej.2006.9.245
Haley, 1980, Lysosomal acid cholesteryl esterase activity in normal and lipid-laden aortic cells, J Lipid Res, 21, 961, 10.1016/S0022-2275(20)34756-8
Davis, 1985, Role of acid lipase in cholesteryl ester accumulation during atherogenesis. Correlation of enzyme activity with acid lipase-containing macrophages in rabbit and human lesions, Atherosclerosis, 55, 205, 10.1016/0021-9150(85)90099-1
Emanuel, 2014, Induction of lysosomal biogenesis in atherosclerotic macrophages can rescue lipid-induced lysosomal dysfunction and downstream sequelae, Arterioscler Thromb Vasc Biol, 34, 1942, 10.1161/ATVBAHA.114.303342
Sergin, 2017, Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis, Nat Commun, 8, 15750, 10.1038/ncomms15750
Wild, 2011, A genome-wide association study identifies LIPA as a susceptibility gene for coronary artery disease. Circulation, Cardiovasc Genet, 4, 403, 10.1161/CIRCGENETICS.110.958728
2011, A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease, Nat Genet, 43, 339, 10.1038/ng.782
Consortium, 2011, Large-scale gene-centric analysis identifies novel variants for coronary artery disease, PLoS Genet, 7, e1002260, 10.1371/journal.pgen.1002260
Willer, 2013, Discovery and refinement of loci associated with lipid levels, Nat Genet, 45, 1274, 10.1038/ng.2797
Consortium, 2017, Genetic effects on gene expression across human tissues, Nature, 550, 204, 10.1038/nature24277
Nedelec, 2016, Genetic ancestry and natural selection drive population differences in immune responses to pathogens, Cell, 167, 657, 10.1016/j.cell.2016.09.025
Morris, 2017, Coronary artery disease-associated LIPA coding variant rs1051338 reduces lysosomal acid lipase levels and activity in lysosomes, Arterioscler Thromb Vasc Biol, 37, 1050, 10.1161/ATVBAHA.116.308734
Zhang, 2017, LIPA variants in genome-wide association studies of coronary artery diseases: loss-of-function or gain-of-function?, Arterioscler Thromb Vasc Biol, 37, 1015, 10.1161/ATVBAHA.117.309344
Zhang, 2015, Functional analysis and transcriptomic profiling of iPSC-derived macrophages and their application in modeling Mendelian disease, Circ Res, 117, 17, 10.1161/CIRCRESAHA.117.305860
Zhang, 2017, Human induced pluripotent stem cell-derived macrophages for unraveling human macrophage biology, Arterioscler Thromb Vasc Biol, 37, 2000, 10.1161/ATVBAHA.117.309195
Burton, 2015, A phase 3 trial of sebelipase alfa in lysosomal acid lipase deficiency, N Engl J Med, 373, 1010, 10.1056/NEJMoa1501365
Jones, 2017, Survival in infants treated with sebelipase Alfa for lysosomal acid lipase deficiency: an open-label, multicenter, dose-escalation study, Orphanet J Rare Dis, 12, 25, 10.1186/s13023-017-0587-3