Low-level environmental exposure to lead and renal adverse effects: A cross-sectional study in the population of children bordering the Mbeubeuss landfill near Dakar, Senegal

Human and Experimental Toxicology - Tập 31 Số 12 - Trang 1280-1291 - 2012
Marta Cabral1,2, Denis Dieme1,2, Anthony Verdin2, Guillaume Garçon2, Mamadou Fall1, S. Bouhsina2, Dorothée Dewaële3, Fabrice Cazier3, A Tall-Dia4, A. Diouf1, Pirouz Shirali2
1Laboratoire de Chimie Analytique et Toxicologie, Faculté de Médecine de Pharmacie et d'Odontologie, Université Cheikh Anta Diop, Dakar, Sénégal
2Unité de Chimie Environnementale et Interactions sur le Vivant (UCEIV), Maison de la Recherche en Environnement Industriel 2, Université du Littoral Côte d’Opale, Dunkerque, France
3Centre Commun de Mesures, Maison de la Recherche en Environnement Industriel de Dunkerque 1, Université du Littoral Côte d’Opale, Dunkerque, France
4Institut de santé et développement, Université Cheikh Anta Diop, Dakar, Sénégal

Tóm tắt

This study deals with the health effects within a child population, neighbouring a landfill. After detecting metals in soil and air samples collected in the surroundings of the landfill and in a control site, we have studied: (i) levels of lead (Pb) and exposure biomarkers in blood and urine, (ii) oxidative stress biomarkers and (iii) renal injury by applying a set of early effect biomarkers. Levels of Pb were higher in the exposed site (i.e. 1129 mg/kg and 640 ng/m3 in soil and air samples, respectively) versus those in the control site (i.e. 14.3 mg/kg and 9.3 ng/m3 in soil and air samples, respectively). Pb impregnation and levels of delta-aminolevulinic acid in urine were influenced by the living site that shows the prevailingly alarming situation in the Mbeubeuss landfill. Malondialdehyde changes indicated Pb-induced excessive production of reactive oxygen species. Lactate dehydrogenase activities and proteinuria were found to be higher in the children living in the exposed site. These evidences may reveal the usefulness of these two effect biomarkers to monitor the kidney injury entailed by relatively low-environmental exposure to Pb. Overall, these results show that the Mbeubeuss landfill constitutes a real source of environmental and health risk, be it living or working on site, of the surrounding population, predominantly for children.

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Thông tin xuất bản

Human and Experimental Toxicology

Tập 31 Số 12

1280-1291

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