Longitudinal trends in HbA1c patterns and association with outcomes: A systematic review

Diabetes/Metabolism Research and Reviews - Tập 34 Số 6 - 2018
Miyang Luo1, Kok Hian Tan1, Chuen Seng Tan1, Wei Yen Lim1, E Shyong Tai2,1, Kavita Venkataraman1
1Saw Swee Hock School of Public Health, National University of Singapore, Singapore
2Division of Endocrinology, National University Hospital, Singapore

Tóm tắt

AbstractBackgroundThis study aimed to review studies that identified patterns of longitudinal HbA1c trends in patients with diabetes and to summarize factors and outcomes associated with distinct trajectory patterns.MethodsPubMed and Web of Science were systematically searched for studies examining HbA1c trends among patients with diabetes from database inception through September 2017. Articles were included if they met the following inclusion criteria: (a) longitudinal study of subjects with diabetes only, (b) use of serial measurements of HbA1c, and (c) analysis of the trend of HbA1c using group‐based trajectory approaches.ResultsTwenty studies were included, 11 on type 1 diabetes and 9 on type 2 diabetes. These studies identified 2 to 6 HbA1c trajectory patterns. The most commonly identified patterns included stable HbA1c around 7.0% and at levels between 8.0% and 9.9%, which usually captured the HbA1c pattern among the majority of subjects in the study population. Unstable patterns identified included increasing HbA1c trend, decreasing HbA1c trend, and non‐linear patterns. These patterns were associated with differential risk of disease outcomes, over and beyond single‐point HbA1c measures. Age, gender, ethnicity, diabetes duration, disease management frequency, cardiovascular risk factors, insulin treatment, family environment, and psychosocial factors were the most frequently reported factors associated with membership of specific HbA1c pattern groups.ConclusionCommon patterns of longitudinal HbA1c trends were identified despite heterogeneity among the studies. A better understanding of what underlies these different patterns may provide opportunities to tailor therapies and care for these patients to reduce adverse outcomes.

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Tài liệu tham khảo

American Diabetes Association. 5. Glycemic Targets, 2016, Standards of medical care in diabetes, Diabetes Care, S39

Group UKPDS, 1998, Intensive blood‐glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33), The Lancet, 352, 837, 10.1016/S0140-6736(98)07019-6

10.1056/NEJMoa0802987

10.1016/j.jpeds.2006.12.009

10.1007/s00125-012-2700-4

10.2337/dc15-1188

10.1016/j.jacc.2013.04.031

10.1093/aje/kwq070

10.1146/annurev.clinpsy.121208.131413

10.1016/j.jclinepi.2012.04.010

10.1016/j.jad.2015.12.030

10.1007/978-0-387-71165-2_2

LuoM TanH LimW.HbA1ctrajectories and outcome among diabetes patients. Available fromhttp://www.crd.york.ac.uk/PROSPERO/display_record.asp?ID=CRD42015019692

Liberati A, 2009, The PRISMA statement for reporting systematic reviews and meta‐analyses of studies that evaluate healthcare interventions: explanation and elaboration, BMJ (Clinical Research Ed), 2700, 339

10.2337/dc17-S003

10.1007/s10654-010-9491-z

WellsGA SB O'ConnellD PetersonJ WelchV LososM et al.The Newcastle‐Ottawa Scale (NOS) For assessing the quality of nonrandomised studies in meta‐analyses 2014[8 June 2015]. Available from: main file with tracked change kv.docx.

10.1016/j.ijsu.2014.07.013

10.1371/journal.pmed.1000100

10.1037/hea0000025

10.2337/dc13-0980

10.1080/07448481.2015.1068780

10.1016/j.jadohealth.2011.09.007

Chang HY, 2014, Management trajectories in the type 2 diabetes integrated delivery system project in Taiwan: accounting for behavioral therapy, nutrition education and therapeutics, Asia Pac J Clin Nutr, 23, 592

10.1016/j.jdiacomp.2016.07.023

10.1007/s00592-014-0633-8

10.1016/j.diabres.2017.08.013

10.1007/s11606-010-1600-x

Control TD, 1993, The effect of intensive treatment of diabetes on the development and progression of long‐term complications in insulin‐dependent diabetes mellitus, New England Journal of Medicine, 329, 977, 10.1056/NEJM199309303291401

10.1016/j.diabres.2014.09.045

10.2337/diacare.24.2.239

10.1067/mpd.2001.116283

10.1111/j.1399-5448.2007.00260.x

10.1016/j.jpeds.2009.05.025

10.1111/j.1399-5448.2010.00650.x

10.4274/Jcrpe.663

10.1016/j.jpeds.2012.12.010

10.1007/s00125-015-3790-6

10.1016/j.jpeds.2006.05.039

10.1093/jpepsy/jsm009

10.1111/j.1399-5448.2008.00370.x

10.1093/jpepsy/jsn012

10.1111/j.1751-9004.2011.00421.x

Viner RM, 2016, Impact of deprivation, ethnicity, and insulin pump therapy on developmental trajectories of diabetes control in COB type 1 diabetes, Pediatr Diabetes

10.2337/dc16-1625

10.1016/j.jdiacomp.2007.11.003

10.1186/1471-2458-5-36

Rekeneire N, 2003, Racial differences in glycemic control in a well‐functioning older diabetic population, Findings from the Health, Aging and Body Composition study, 26, 1986

10.1016/j.jdiacomp.2008.12.008

Richardson LK, 2008, Longitudinal effects of depression on glycemic control in veterans with type 2 diabetes, Gen Hosp Psychiatry, 30, 509, 10.1016/j.genhosppsych.2008.07.001

10.2337/diacare.27.3.752

10.1097/MLR.0b013e31806728e9

10.1053/beem.1999.0017

10.1016/S0140-6736(98)07019-6

10.2337/dc08-1990

10.1016/j.jadohealth.2012.05.009

10.2337/dc10-1405

10.1093/jpepsy/jsq011

10.1177/0145721715593814

10.1111/pedi.12100

10.1111/dme.13110

10.1371/journal.pone.0097384

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Diabetes/Metabolism Research and Reviews

Tập 34 Số 6

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