Longitudinal patterns of potentially inappropriate medication use following incident dementia diagnosis

Alzheimer's and Dementia: Translational Research and Clinical Interventions - Tập 4 - Trang 1-10 - 2018
Christine M. Ramsey1, Danijela Gnjidic2, George O. Agogo1, Heather Allore1,3, Daniela Moga4,5,6
1Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA
2Faculty of Pharmacy and Charles Perkins Centre, University of Sydney, Camperdown, New South Wales, Australia
3Department of Biostatistics, Yale School of Public Health, New Haven, CT, USA
4Department of Pharmacy Practice and Science, University of Kentucky College of Pharmacy, Lexington, KY, USA
5Department of Epidemiology, University of Kentucky, College of Public Health, Lexington, KY, USA
6University of Kentucky, Sanders-Brown Center on Aging, Lexington, KY, USA

Tóm tắt

AbstractIntroduction

Potentially inappropriate medication (PIM) use in older adults with dementia is an understudied area. We assessed longitudinal changes in PIM exposure by dementia type following dementia diagnosis.

Methods

We followed 2448 participants aged ≥65 years (52% women, 85.5% Caucasian, mean age 80.9 ± 7.5 years) diagnosed with dementia after enrollment in the National Alzheimer's Coordinating Center (2005–2014). We estimated the association between dementia type and PIM annually for 2 years after diagnosis, using Generalized Estimating Equations.

Results

Participants with Lewy body dementia had more PIM use, and participants with frontotemporal dementia had less PIM use than participants with Alzheimer's disease. In the first year following diagnosis, total number of medications increased, on average, by 10% for Alzheimer's disease and 15% for Lewy body dementia (P < .05 for both).

Discussion

A tailored approach aimed at optimizing drug therapy is needed to mitigate PIM exposure to improve medical care for individuals with dementia.


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Alzheimer's and Dementia: Translational Research and Clinical Interventions

Tập 4

1-10

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