Longitudinal Profiling of Inflammatory Cytokines and C‐reactive Protein during Uncomplicated and Preterm Pregnancy

American Journal of Reproductive Immunology - Tập 72 Số 3 - Trang 326-336 - 2014
Kelly K. Ferguson1, Thomas F. McElrath2, Yin‐Hsiu Chen3, Bhramar Mukherjee3, John D. Meeker1
1Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA
2Division of Maternal and Fetal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
3Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA

Tóm tắt

ProblemPrevious studies have investigated the utility of inflammation markers as predictors of preterm birth, but none have compared trends in levels between uncomplicated and preterm pregnancy.Method of studyWe explored longitudinal changes in plasma cytokines, including IL‐1β, IL‐6, IL‐10, and TNF‐α, as well as C‐reactive protein in pregnant women from a nested case–control study.ResultsIL‐6 was associated with increased odds of spontaneous preterm birth, defined by presentation of spontaneous preterm labor and/or preterm premature rupture of the membranes. Associations were strongest later in pregnancy. IL‐10 was associated with increased odds of placentally mediated preterm birth, defined by presentation with preeclampsia or intrauterine growth restriction, and odds ratios were also highest near the end of pregnancy.ConclusionMaternal inflammation markers were associated with increased risk of preterm birth, and relationships differed by etiology of preterm delivery and gestational age at sample collection.

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Thông tin
Thông tin xuất bản

American Journal of Reproductive Immunology

Tập 72 Số 3

326-336

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