Longitudinal Assessment of Erythrocyte Fatty Acid Composition Throughout Pregnancy and Post Partum

Lipids - Tập 42 - Trang 335-344 - 2007
Frances Stewart1, Vanessa A. Rodie1, Jane E. Ramsay1, Ian A. Greer1, Dilys J. Freeman1, Barbara J. Meyer2
1Division of Developmental Medicine, University of Glasgow, Royal Infirmary, Glasgow, UK
2School of Health Sciences, University of Wollongong, Wollongong, Australia

Tóm tắt

Transfer of fatty acids from mother to fetus during pregnancy is a requirement for optimal fetal growth. We report a longitudinal study of full maternal erythrocyte fatty acid profile assessed at each trimester of pregnancy [mean 12.5 (range 8–14), 26.1 (24–28) and 35.5 (33–38) weeks’ gestation] and in the post partum period [18.1 (12–26) weeks]. The study recruited healthy women (n = 47) from routine antenatal clinics at the Princess Royal Maternity Unit, Glasgow, Scotland. There were increases in 16:1n7 (22%, p = 0.0005), 24:1n9 (13%, p = 0.0032), 22:5n6 (25%, p = 0.0003), 18:3n3 (41%, p = 0.0007) and 22:6n3 (20%, p = 0.0005) concentrations during pregnancy. The greatest increases took place between gestations at sampling of 12.5 and 26.1 weeks. The change in 16:1n7 concentration between gestations at sampling of 12.5 and 35.3 weeks was negatively associated with maternal booking body mass index (r = −0.40, p = 0.006). The change in 22:6n3 concentration was correlated with the change in 24:1n9 (r = 0.70, p < 0.001). In samples taken four months post partum, 14:0 concentration was lower (29%, p = 0.0002) and 24:0 concentration (15%, p = 0.0009) and n6/n3 ratio (11%, p = 0.0019) were higher than at a gestation at sampling of 12.5 weeks. In conclusion, several fatty acids are specifically mobilised during pregnancy. The correlation between maternal 22:6n3 and 24:1n9 suggests that mobilisation of these fatty acids may be coordinated. The inverse relationship between 16:1n7 and maternal central obesity warrants further investigation.

Tài liệu tham khảo