Long‐term risk of second malignant neoplasms after neuroblastoma in childhood: Role of treatment

International Journal of Cancer - Tập 107 Số 5 - Trang 791-796 - 2003
Carolé Rubino1, Élisabeth Adjadj1, Sylvie Guérin1, Catherine Guibout1, Akhtar Shamsaldin2,1, Marie‐Gabrielle Dondon1, Dominique Valteau‐Couanet3, Olivier Hartmann3, Mike Hawkins4, Florent de Vathaire1
1Research Unit of Cancer Epidemiology (XU521 INSERM), Institut Gustave Roussy, Villejuif, France
2Department of Medical Physics and Radiotherapy, Institut Gustave Roussy, Villejuif, France
3Department of Pediatrics, Institut Gustave Roussy, Villejuif, France
4Centre for Childhood Cancer Survivor Studies, Department of Public Health and Epidemiology, University of Birmingham, Birmingham, United Kingdom

Tóm tắt

AbstractThe aim of our study was to quantify the risk of second malignant neoplasms (SMNs) among long‐term survivors of neuroblastoma and to study the influence of treatment on this risk. We studied data from 544 5‐year survival patients diagnosed with neuroblastoma before age 16 years at 8 French and British treatment centres from 1948 to 1986. After an average follow‐up of 15 years (range, 5–38 years), 12 children developed a total of 13 SMNs, whereas 1.19 were expected from general population rates. Among these SMNs, there were 5 thyroid and 3 breast cancers. Increases of the risks of SMN were observed with time since neuroblastoma diagnosis and attained age. In a multivariate analysis, the relative risk of SMN associated with radiotherapy was 4.3 (95% CI 0.8–78), whereas no increased risk of SMN was associated with the administration of chemotherapy as a whole (RR = 0.4, 95% CI 0.1–1.9). Young children treated for a neuroblastoma have significantly increased risks of SMN over 3 decades of follow‐up. Radiotherapy treatment was found to be an important risk factor for developing SMNs, whereas no effect of chemotherapy was evidenced. Although our findings reflect the late effects of past therapeutic modalities, they underscore the importance of long‐term surveillance of young children treated for a neuroblastoma. For these patients, many more years of follow‐up are required to appreciate their overall risks of treatment‐related SMNs. © 2003 Wiley‐Liss, Inc.

Từ khóa


Tài liệu tham khảo

Tucker MA, 1984, Radiation carcinogenesis: epidemiology and biological significance, 211

10.1038/bjc.1987.200

10.1136/bmj.307.6911.1030

10.1038/sj.bjc.6690300

10.1093/jnci/93.8.618

Meadows AT, 1992, Late effects of early childhood cancer therapy, Br J Cancer, 66, S92

10.1016/0002-9343(92)90680-A

10.1136/bmj.304.6832.951

10.1038/bjc.1992.87

10.1002/cncr.11167

Grimaud E, 1994, Programme original de calcul de dose appliqué à l'étude de seconds cancers, Bull Cancer Radiother, 81, 482

10.1016/S0167-8140(98)00110-8

MenegozF Cherié‐ChallineL.Le cancer en France: incidence et mortalité. Situation en 1995. Evolution entre 1975 et 1995. Reseau FRANCIM.2000.

Office for National Statistics, 1999, Cancer 1971–1997 CD‐ROM

Breslow NE, 1987, Statistical methods in cancer research. vol. II. The design and analysis of cohort studies, IARC Sci Publ, 82, 1

Preston DL, 1993, EPICURE user's guide

10.2307/2347496

10.1016/S0022-3468(05)80325-2

10.1002/ijc.2910590402

10.1200/JCO.1998.16.12.3880

10.1002/1097-0215(20001115)88:4<672::AID-IJC24>3.0.CO;2-N

10.1016/S0360-3016(01)02713-4

10.1002/(SICI)1096-9098(199611)63:3<172::AID-JSO7>3.0.CO;2-A

10.1002/(SICI)1096-911X(199801)30:1<18::AID-MPO7>3.0.CO;2-3

10.1001/archinte.159.22.2713

10.1002/mpo.1122

10.1056/NEJM198709033171002

10.1093/jnci/88.5.270

10.1002/1097-0142(19910101)67:1<193::AID-CNCR2820670132>3.0.CO;2-B

10.1046/j.1365-2141.2001.03000.x

10.1200/JCO.2003.04.100

10.1002/(SICI)1097-0215(19980729)77:3<370::AID-IJC11>3.0.CO;2-C

Menu‐BranthommeA RubinoC ShamsaldinA HawkinsMM GrimaudE DodonMG HardimanC VassalG CampbellS PanisX Daly‐SchveitzerN LagrangeJL et al. Radiation dose chemotherapy and risk of soft‐tissue sarcomas after solid tumors during childhood. Int J Cancer submitted.

10.1056/NEJM199703273361301

10.1200/JCO.2000.18.2.348

10.1016/S0959-8049(97)00324-9

Thông tin
Thông tin xuất bản

International Journal of Cancer

Tập 107 Số 5

791-796

Thông tin tác giả