Bin Wang1, Li Wang1, Xianggen Kong1, Jin Geng1, Xiao Di1, Chunhong Ma2, Xuemei Jiang1, Pei‐Hui Wang2
1Jinan Infectious Diseases Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China
2Advanced Medical Research Institute, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China
Tóm tắt
AbstractSevere acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection causing coronavirus disease 2019 (COVID‐19) has spread worldwide. Whether antibodies are important for the adaptive immune responses against SARS‐CoV‐2 infection needs to be determined. Here, 26 cases of COVID‐19 in Jinan, China, were examined and shown to be mild or with common clinical symptoms, and no case of severe symptoms was found among these patients. Strikingly, a subset of these patients had SARS‐CoV‐2 and virus‐specific IgG coexist for an unexpectedly long time, with two cases for up to 50 days. One COVID‐19 patient who did not produce any SARS‐CoV‐2–bound IgG successfully cleared SARS‐CoV‐2 after 46 days of illness, revealing that without antibody‐mediated adaptive immunity, innate immunity alone may still be powerful enough to eliminate SARS‐CoV‐2. This report may provide a basis for further analysis of both innate and adaptive immunity in SARS‐CoV‐2 clearance, especially in nonsevere cases.
