Long-acting MIC-1/GDF15 molecules to treat obesity: Evidence from mice to monkeys

American Association for the Advancement of Science (AAAS) - Tập 9 Số 412 - 2017
Yumei Xiong1, Kenneth W. Walker2, Xiaoshan Min3, Clarence Hale4, Thanhvien Tran1, Renée Komorowski4, Jerry Yang1, Jasmine Davda5, Noi Nuanmanee2, Dao Kemp2, Xiaozhen Wang6, Hantao Liu7, Silke Miller7, Ki Jeong Lee2, Zhulun Wang2, Murielle M. Véniant4
1Department of Cardiometabolic Disorders, Amgen Inc., 1120 Veterans Boulevard, South San Francisco, CA 94080, USA.
2Department of Therapeutic Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA.
3Department of Therapeutic Discovery, Amgen Inc., 1120 Veterans Boulevard, South San Francisco, CA 94080, USA
4Department of Cardiometabolic Disorders, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA.
5Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., 1120 Veterans Boulevard, South San Francisco, CA 94080, USA.
6Department of Medical Sciences, Amgen Inc., 1120 Veterans Boulevard, South San Francisco, CA 94080, USA.
7Department of Neuroscience, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA

Tóm tắt

Engineered long-acting GDF15-Fc fusion molecules reduce food intake and body weight and improve metabolic profiles in animal models of obesity.

Từ khóa


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American Association for the Advancement of Science (AAAS)

Tập 9 Số 412

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