Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes

American Association for the Advancement of Science (AAAS) - Tập 329 Số 5992 - Trang 689-693 - 2010
Miao-Chih Tsai1, Ohad Manor2, Yue Wan1, Nima Mosammaparast3, Jordon K. Wang1, Fei Lan4,3, Yang Shi3, Eran Segal2, Howard Y. Chang1
1Howard Hughes Medical Institute and Program in Epithelial Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
2Department of Computer Science & Applied Mathematics, Weizmann Institute of Science Rehovot, 76100, Israel#TAB#
3Department of Pathology, Harvard Medical School, and Division of New Born Medicine, Department of Medicine, Children’s Hospital Boston, Boston, MA 02138, USA.
4Constellation Pharmaceuticals, 215 First Street, Suite 200, Cambridge, MA 02142, USA

Tóm tắt

A Lot of HOTAIR The roles of several classes of small (<50 nucleotides) noncoding RNAs are beginning to be defined in molecular detail, whereas the function of most of the long (∼200+ nucleotides), intergenic noncoding (linc)RNAs found in most eukaryotic genomes remains something of a mystery. The HOTAIR lincRNA, which is transcribed from the mouse HOXC locus, binds to the Polycomb Repressive Complex 2 (PRC2) and recruits it to HOXD and other genes, where its histone methylase activity acts to repress gene transcription. Tsai et al. (p. 689 , published online 8 July) now show that HOTAIR also binds to a histone demethylase enzyme, LSD1, part of the CoREST/REST repressor complex. LSD1 acts to remove transcription-activating histone marks, reinforcing the repressive activity of the PRC2 complex. HOTAIR thus functions as a platform for the coordinated binding of PRC2 and LSD1-containing complexes to genes, as revealed in a genome-wide analysis of PRC1/CoREST/REST co-regulated genes.

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American Association for the Advancement of Science (AAAS)

Tập 329 Số 5992

689-693

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