Localized high‐resolution proton NMR spectroscopy using stimulated echoes: Initial applications to human brain <i>in vivo</i>

Magnetic Resonance in Medicine - Tập 9 Số 1 - Trang 79-93 - 1989
Jens Frahm1, H Bruhn1, Michael L. Gyngell1, Klaus‐Dietmar Merboldt1, W. Hänicke1, R. Sauter2
1Max-Planck-institut für biophysikalische Chemie, Postfach 2841 D-3400 Goöuingen, Federal Republic of Germany
2Bereich Medizinische Technik, Siemens AG, Henkestrasse 27, D-8520 Erlangen, Federal Republic of Germany

Tóm tắt

AbstractWater‐suppressed localized proton NMR spectroscopy using stimulated echoes has been successfully applied to detect metabolites in the human brain in vivo. The STEAM spectroscopy sequence allows single‐step localization by exciting three intersecting slices. Water suppression is achieved by preceding chemical‐shift‐selective (CHESS) rf pulses. High‐resolution (0.05 ppm) proton NMR spectra of healthy volunteers have been obtained on a conventional 1.5‐T whole‐body MRI system (Siemens Magnetom). Volumes‐of‐interest (VOI) of 64 ml(4 × 4 × 4 cm3) were localized in the occipital area of the brain and spectra were recorded within measuring times ranging from I s (single scan) to about 10 min. The experimental procedure is described in detail. Resonance assignments include acetate, N‐acetyl aspartate, γ‐amino butyrate, glutamine, glutamate, aspartate, creatine and phosphocreatine, choline‐containing compounds, taurine, and inositols. Cerebral lactate was found to be at a maximum concentration of 0.5 mM when assuming N‐acetyl aspartate in white matter to be 6 mM. © 1989 Academic Press, Inc.

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Magnetic Resonance in Medicine

Tập 9 Số 1

79-93

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