Local recurrence of sclerosing mucoepidermoid carcinoma with eosinophilia in the upper lip: a case report

Yoshikazu Kobayashi1, Koji Satoh1, Takako Aizawa1, Makoto Urano2, Makoto Kuroda2, Hideki Mizutani1
1Department of Oral and Maxillofacial Surgery, Fujita Health University School of Medicine, Toyoake, Japan
2Department of Diagnostic Pathology, Fujita Health University School of Medicine, Toyoake, Japan

Tóm tắt

Sclerosing mucoepidermoid carcinoma with eosinophilia is a rare morphological variant of thyroid carcinoma associated with Hashimoto’s disease. To date, only three such tumors have been reported in the minor salivary glands. We describe the first case, to the best of our knowledge, of recurrent sclerosing mucoepidermoid carcinoma with eosinophilia in the minor salivary glands of the upper lip. A 61-year-old Japanese man was referred to our hospital with a mass in his median upper lip of four years’ duration. An examination of his median upper lip revealed a well-defined tumor measuring 9×12mm in diameter, which was subsequently resected. Three years after the first surgery, the tumor recurred and was resected. Both tumors were confirmed by histopathology to be sclerosing mucoepidermoid carcinoma with eosinophilia. Neither recurrence nor metastasis was observed in three and a half years of follow-up after the second surgery. Our findings indicate that sclerosing mucoepidermoid carcinoma with eosinophilia can originate in the minor salivary glands and may be clinically or pathologically misdiagnosed as other conditions.

Từ khóa


Tài liệu tham khảo

Chan JK, Albores-Saavedra J, Battifora H, Carcangiu ML, Rosai J. Sclerosing mucoepidermoid thyroid carcinoma with eosinophilia: a distinctive low-grade malignancy arising from the metaplastic follicles of Hashimoto’s thyroiditis. Am J Surg Pathol. 1991;15:438–48. Das S, Kalyani R. Sclerosing mucoepidermoid carcinoma with eosinophilia of the thyroid. Indian J Pathol Microbiol. 2008;51:34–6. Chan JKC, Saw D. Sclerosing mucoepidermoid tumor of the parotid gland: report of a case. Histopathology. 1987;11:203–7. Muller S, Barnes L, Goodurn Jr WJ. Sclerosing mucoepidermoid carcinoma of the parotid. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1997;83:685–90. Sinha SK, Keogh IJ, Russell JD, O'Keane JC. Sclerosing mucoepidermoid carcinoma of minor salivary glands: a case report. Histopathology. 1999;35:283–4. Urano M, Abe M, Horibe Y, Kuroda M, Mizoguchi Y, Sakurai K, et al. Sclerosing mucoepidermoid carcinoma with eosinophilia of the salivary glands. Pathol Res Pract. 2002;198:305–10. Fadare O, Hileeto D, Gruddin YL, Mariappan MR. Sclerosing mucoepidermoid carcinoma of the parotid gland. Arch Pathol Lab Med. 2004;128:1046–9. Ide F, Obara K, Enatsu K, Mishima K, Saito I. Sclerosing mucoepidermoid carcinoma of the oral cavity. J Oral Pathol Med. 2005;34:187–9. Heavner SB, Shah RB, Moyer JS. Sclerosing mucoepidermoid carcinoma of the parotid gland. Eur Arch Otorhinolaryngol. 2006;263:955–9. Veras EF, Sturgis E, Luna MA. Sclerosing mucoepidermoid carcinoma of the salivary glands. Ann Diagn Pathol. 2007;11:407–12. Aguiar MC, Bernardes VF, Cardoso SV, Barbosa AA, Mesquita RA, Carmo MA. A rare case of sclerosing mucoepidermoid carcinoma arising in minor salivary glands with immunohistochemical evaluation. Minerva Stomatol. 2008;57:453–7. Shinhar SY. Sclerosing mucoepidermoid carcinoma of the parotid gland: case report. Ear Nose Throat J. 2009;88:E29–31. Mendelson AA, al-Macki K, Chauvin P, Kost KM. Sclerosing mucoepidermoid carcinoma of the salivary gland: Case report and literature review. Ear Nose Throat J. 2010;89:600–3. Tian W, Yakirevich E, Matoso A, Gnepp DR. IgG4(+) plasma cells in sclerosing variant of mucoepidermoid carcinoma. Am J Surg Pathol. 2012;36:973–9. Tasaki T, Matsuyama A, Tabata T, et al. Sclerosing mucoepidermoid carcinoma with eosinophilia of the salivary gland: case report and review of the literature. Pathol Int. 2013;63:125–31. Goode RK, El-Naggar AK. Mucoepidermoid carcinoma. In: Leon B, John WE, Peter R, David S, editors. Pathology and genetics of head and neck tumours (World Health Organization Classification of Tumours). Lyon: IARC Press; 2005. p. 219–20. Cheuk W, Chan JKC. Advances in salivary gland pathology. Histopathology. 2007;51:1–20. Lowe D, Jorizzo J, Hutt MS. Tumour-associated eosinophilia: a review. J Clin Pathol. 1981;34:1343–8. Cormier SA, Taranova AG, Bedient C, Nguyen T, Protheroe C, Pero R, et al. Pivotal advance: eosinophil infiltration of solid tumors is an early and persistent inflammatory host response. J Leukoc Biol. 2006;79:1131–9. Thompson AC, Bradley PJ, Griffin NR. Tumor-associated tissue eosinophilia and long-term prognosis for carcinoma of the larynx. Am J Surg. 1994;168:469–71. Tadbir AA, Ashraf MJ, Sardari Y. Prognostic significance of stromal eosinophilic infiltration in oral squamous cell carcinoma. J Craniofac Surg. 2009;20:287–9. von Wasielewski R, Seth S, Franklin J, Fischer R, Hübner K, Hansmann ML, et al. Tissue eosinophilia correlates strongly with poor prognosis in nodular sclerosing Hodgkin's disease, allowing for known prognostic factors. Blood. 2000;95:1207–13. Samoszuk M. Eosinophils and human cancer. Histol Histopathol. 1997;12:807–12.