Local cerebral glucose utilization in the autoimmune New Zealand Black (NZB) mouse

Springer Science and Business Media LLC - Tập 92 - Trang 343-348 - 1989
A. Wree1, T. Beck2, G. W. Bielenberg2, A. Schleicher3, K. Zilles3
1Anatomisches Institut der Universität Würzburg, Würzburg, Germany
2Institut für Pharmakologie und Toxikologie, Fachbereich Pharmazie und Lebensmittelechemie der Universität Marburg, Marburg, Germany
3Anatomisches Institut der Universität Köln, Köln 41, Germany

Tóm tắt

By means of the [14C]-2-deoxyglucose method the local cerebral glucose utilization (LCGU) was measured in 41 brain regions in autoimmune New Zealand Black (NZB) mice and in Carworth Farm Winkelmann (CFW) mice, which served as the control strain. At the age of 6 months, the mean LCGU of all measured areas and brain stem nuclei was 67.7 μmol glucose/(100 g x min) in the nonautoimmune CFW mice. These LCGU values are within the limits published by other observers. In contrast, in the aged-matched NZB mice the glucose use was markedly reduced, the mean LCGU of all measured areas being 37.7 μmol glucose/(100 g x min). These findings suggest that the immunological, morphological and behavioural abnormalities in the aged NZB mouse correlate with a reduced functional activity of the central nervous system, measured as reduced cerebral glucose utilization.

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Springer Science and Business Media LLC

Tập 92

343-348

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