Local anesthetic improves individuals affected with herpes simplex type 1 labialis

Journal of Medical Virology - Tập 92 Số 12 - Trang 3638-3644 - 2020
Mônica Danielle Ribeiro Bastos1, Fellipe Augusto Tocchini de Figueiredo1, Ana Paula Macedo1, Amanda Cristina Funari Silva2, Maíra P. Ferreira2, Osvaldo de Freitas2, Vinícius Pedrazzi1
1Department of Dental Materials and Prothesis, School of Dentistry of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
2Department of Pharmaceutical Sciences, School of Pharmaceutical Sciences of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil

Tóm tắt

AbstractInfections caused by the herpes simplex virus 1 (HSV‐1), commonly called herpes simplex labialis (HSL), are a public health problem, reaching around 40% of the world's population. Thus, the search for effective therapeutic alternatives in the control of the limitations caused by this virus during the stages of evolution of the disease, is necessary, since they have a direct impact on the quality of life of the patients. The aim of the present study was to evaluate the efficacy of the in situ film precursor semisolid composition in the treatment of herpes simplex lesions in human HSV‐1. Ninety‐eight (n = 98) patients with HSV‐1 were used for this study. The initial exclusion criteria left 81 patients to be considered in the present study. Three applications were performed, the first at time zero (T0) and the other two at 8 and 16 hours, after initial application (T8 and T16). Photographs were taken in the first appointment and 24 and 72 hours after the last application. After the three periods, each patient received a total amount of 90 mg of anesthetic and the prognosis of the patients was followed for 6 months and 1 year after the application. Frequency analysis showed that 40.3% of patients had remission of symptoms 24 hours after the last application. For the present study, the film presented a positive therapeutic potential and an esthetic benefit that is absent in the current products (ointments and gels). The invent presents dosage convenience (only three applications in a 24‐hour period) and a low production cost, with a much shorter healing time than that reported using topical antiretrovirals.

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Journal of Medical Virology

Tập 92 Số 12

3638-3644

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