Local Cerebral Glucose Metabolism During Controlled Hypoxemia in Rats
Tóm tắt
2-Deoxy-[ 14 C]glucose metabolism was examined in brains of hypoxic, normotensive rats by autoradiography, which revealed alternating cortical columns of high and low metabolism. Activity in white matter was increased severalfold over that in adjacent gray matter. The columns were anatomically related to penetrating cortical arteries with areas between arteries demonstrating higher rates of metabolism. The results suggest the presence of interarterial tissue oxygen gradients that influence regional glucose metabolism. The relatively greater sensitivity of white matter metabolism to hypoxia may lead to an understanding of white matter damage in postanoxic leukoencephalopathy.
Từ khóa
Tài liệu tham khảo
ASANUMA, H, RECENT DEVELOPMENTS IN STUDY OF COLUMNAR ARRANGEMENT OF NEURONS WITHIN MOTOR CORTEX, PHYSIOLOGICAL REVIEWS 55: 143 (1975).
BERNTMAN, L, CEREBRAL OXYGEN-CONSUMPTION AND BLOOD-FLOW IN HYPOXIA - INFLUENCE OF SYMPATHOADRENAL ACTIVATION, STROKE 10: 20 (1979).
BRIERLEY J.B. GREENFIELDS NEUROPAT (1976).
DUFFY, T.E., CEREBRAL CARBOHYDRATE METABOLISM DURING ACUTE HYPOXIA AND RECOVERY, JOURNAL OF NEUROCHEMISTRY 19: 959 (1972).
DURHAM, D, BARRELS AND COLUMNAR CORTICAL ORGANIZATION - EVIDENCE FROM 2-DEOXY-GLUCOSE EXPERIMENTS, ANATOMICAL RECORD 187: 570 (1977).
GINSBERG, M.D., HETEROGENEITIES OF REGIONAL CEREBRAL BLOOD-FLOW DURING HYPOXIA-ISCHEMIA IN RAT, STROKE 7: 132 (1976).
HUBEL, D.H., RECEPTIVE FIELDS AND FUNCTIONAL ARCHITECTURE OF MONKEY STRIATE CORTEX, JOURNAL OF PHYSIOLOGY-LONDON 195: 215 (1968).
JOHANNSSON, H, CEREBRAL BLOOD-FLOW AND OXYGEN-CONSUMPTION IN RAT IN HYPOXIC HYPOXIA, ACTA PHYSIOLOGICA SCANDINAVICA 93: 269 (1975).
KENNEDY, C, METABOLIC MAPPING OF PRIMARY VISUAL-SYSTEM OF MONKEY BY MEANS OF AUTORADIOGRAPHIC [DEOXYGLUCOSE-C-14] TECHNIQUE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 73: 4230 (1976).
KROGH, A, The rate of diffusion of gases through animal tissues, with some remarks on the coefficient of invasion., JOURNAL OF PHYSIOLOGY-LONDON 52: 391 (1919).
PLUM, F, DELAYED NEUROLOGICAL DETERIORATION AFTER ANOXIA, ARCHIVES OF INTERNAL MEDICINE 110: 18 (1962).
REIVICH, M, RESEARCH PUBLICATIONS. ASSOCIATION FOR RESEARCH IN NERVOUS AND MENTAL DISEASE 53: 125 (1974).
SAKURADA, O, MEASUREMENT OF LOCAL CEREBRAL BLOOD-FLOW WITH ANTIPYRINE-IODO-C-14, AMERICAN JOURNAL OF PHYSIOLOGY 234: H59 (1978).
SALFORD, L.G., INFLUENCE OF ARTERIAL HYPOXIA AND UNILATERAL CAROTID-ARTERY OCCLUSION UPON REGIONAL BLOOD-FLOW AND METABOLISM IN RAT-BRAIN, ACTA PHYSIOLOGICA SCANDINAVICA 92: 130 (1974).
SALFORD, L.G., GRADED HYPOXIA-OLIGEMIA IN RAT-BRAIN .1. BIOCHEMICAL ALTERATIONS AND THEIR IMPLICATIONS, ARCHIVES OF NEUROLOGY 29: 227 (1973).
SALFORD, L.G., GRADED HYPOXIA-OLIGEMIA IN RAT-BRAIN .2. NEUROPATHOLOGICAL ALTERATIONS AND THEIR IMPLICATIONS, ARCHIVES OF NEUROLOGY 29: 234 (1973).
WELSH, F.A., EFFECT OF OLIGEMIA ON REGIONAL METABOLITE LEVELS IN CAT BRAIN, JOURNAL OF NEUROCHEMISTRY 31: 311 (1978).
WELSH, F.A., REGIONS OF CEREBRAL ISCHEMIA LOCATED BY PYRIDINE-NUCLEOTIDE FLUORESCENCE, SCIENCE 198: 951 (1977).
WIESEL, T.N., AUTORADIOGRAPHIC DEMONSTRATION OF OCULAR-DOMINANCE COLUMNS IN MONKEY STRIATE CORTEX BY MEANS OF TRANSNEURONAL TRANSPORT, BRAIN RESEARCH 79: 273 (1974).