Lipoprotein Metabolism

Drugs - Tập 47 - Trang 1-10 - 2012
James Shepherd1
1Institute of Pathological Biochemistry, Royal Infirmary, Glasgow, Scotland

Tóm tắt

The biological benefits of lipids as sources of energy and precursors of cell components have led to the evolution of a complex plasma lipoprotein transport system, through which gram quantities of cholesterol, triglyceride, and phospholipid pass each day. A wide variety of tissues make demands on this pool. The adrenal glands and gonads avidly assimilate lipoprotein cholesterol for the production of steroid hormones, and rapidly dividing intestinal villus cells take up the sterol for membrane synthesis. Metabolically active tissues such as skeletal muscle use plasma triglyceride for energy production, while in times of surfeit this lipid is directed into adipocytes for storage. Two organs, the liver and intestine, play a particularly important role in corporeal lipid metabolism, and together are responsible for the majority of lipoprotein synthesis and catabolism. In the plasma, lipid transport is regulated by specific apolipoproteins (apo), lipoprotein receptors, lipolytic enzymes and transfer proteins, which act in concert to maintain the balance of cholesterol and triglyceride homeostasis in tissues and plasma; their malfunction may cause or contribute to the development of dyslipidaemia.

Tài liệu tham khảo

Angelin B, Bjorkheim I, Einarsson K. Cholesterol 7α hydroxylase and bile acid synthesis in relation to triglyceride and lipoprotein metabolism. In Fears & Sabine (Eds) Cholesterol 7α hydroxylase, pp. 137–177, CRC Press, Boca Raton, Fla, 1986 Baker SR, Patsch JR, Forte T, Bensadoun A. Plasma lipoprotein changes resulting from immunologically blocked lipolysis. Journal of Lipid Research 22: 443–451, 1981 Barter PJ, Kevin FC. Precursor of plasma triglyceride fatty acid in humans. Effect of glucose consumption, Clofibrate administration and alcoholic fatty liver. Metabolism 21: 117–124, 1972 Berman M, Hall M, Levy RI, et al. Metabolism of Apo B and Apo C lipoproteins in man: kinetic studies in normal and hyperlipopro-teinemic subjects. Journal of Lipid Research 19: 38–56, 1978 Blum CB. Dynamics of apolipoprotein E metabolism in humans. Journal of Lipid Research 23: 1308–1316, 1982 Carlson LS, Holmqvist L, Nilsson-Ehle P. Deficiency of hepatic lipase activity in post heparin plasma in familial hyperalphatriglyceridemia. Acta Medica Scandinavica 219: 435–447, 1986 Chan L, van Tuinen P, Ledbetter DH, et al. The human apolipoprotein B-100 gene: a highly polymorphic gene that maps to the short arm of chromosome 2. Biochemical Biophysical Research Communications 113: 248–255, 1985 Danielson H, Sjövall J. Bile acid metabolism. Annual Review of Biochemistry 44: 233–253, 1975 Da Lalla OF, Elliott HA, Gofman JW. Ultracentrifugal studies of high density serum lipoproteins in clinically healthy adults. American Journal of Physiology 179: 333–337, 1954 Deckelbaum RJ, Olivecrona T, Eisenberg S. Plasma lipoproteins in hyperlipidemia: roles of neutral lipid exchange and lipase. In Carlson et al. (Eds) Treatment of hyperlipoproteinemia, pp. 85–93, Raven Press, New York, 1984 Deckelbaum RJ, Eisenberg S, Oschry Y, Cooper M, Blum CB. Abnormal high density lipoproteins of abetalipoproteinemia. Journal of Lipid Research 23: 1274–1282, 1982 Demant T, Carlson LA, Holmquist C, et al. The metabolism of apo B containing lipoproteins in a patient with hepatic lipase deficiency. Atherosclerosis 74: 255–264, 1988 Dietschy JM, Wilson JD. Regulation of cholesterol metabolism. New England Journal of Medicine 282: 1128–1138, 1179–1183, 1241–1249, 1970 Dory L, Boquet LM, Hamilton RL, Sloop CD, Roheim PS. Heterogeneity of dog intestinal fluid (peripheral lymph high density lipoproteins). Journal of Lipid Research 26: 519–527, 1985 Dory L, Sloop CH, Boquet LM, Hamilton RL, Roheim PS. Lecithin cholesterol acyltransferase mediated modification of discoidal peripheral lymph high density lipoproteins. Proceedings of the National Academy of Sciences of the United States of America 80: 3489–3493, 1983 Eisenberg S. Preferential enrichment of large sized very low density lipoprotein populations with transferred cholesteryl esters. Journal of Lipid Research 26: 487–493, 1985 Ginsberg HN, Ngoc-Anh LE, Goldberg IJR, Brown WV. Apolipoprotein B metabolism in subjects with deficiency of apolipoproteins CIII and AI. Journal of Clinical Investigation 78: 1287–1295, 1986 Gofman JW, Young W, Tandy R. Ischemic heart disease, atherosclerosis and longevity. Circulation 34: 679–697, 1966 Goh EH, Heimberg M. Relationship between the activity of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase and secretion of very low density lipoprotein cholesterol in the isolated perfused liver and in the intact rat. Biochemical Journal 184: 1–6, 1979 Goldberg IJ, Ngoc-Anh Le, Paterniti JR, et al. Lipoprotein metabolism during acute inhibition of hepatic triglyceride lipase in the cynom-olgus monkey. Journal of Clinical Investigation 70: 1184–1192, 1982 Goldstein JL, Brown MS. Progress in understanding the LDL receptor and HMG CoA reductase, two membrane proteins that regulate the plasma cholesterol. Journal of Lipid Research 25: 1450–1462, 1984 Green PHR, Glickman PM. Intestinal lipoprotein metabolism. Journal of Lipid Research 22: 1153–1173, 1981 Green PHR, Glickman RM, Sandel CD, Blum CB, Tall AR. Human intestinal lipoproteins: studies in chyluric subjects. Journal of Clinical Investigation 64: 233–242, 1979 Green PHR, Tall AR, Glickman RM. Rat intestine secretes discoidal high density lipoprotein. Journal of Clinical Investigation 61: 528–534, 1978 Gregg RE, Zech LA, Schaefer EJ, Brewer HB. Type III hyperlipoproteinemia: defective metabolism of an abnormal apolipoprotein E. Science 221: 584–588, 1981 Hamilton RL. Hepatic secretion of nascent plasma lipoproteins. In Glauman et al. (Eds) Plasma protein secretion by the liver, pp. 357–374, Academic Press, London, 1983 Havel RJ, Kane JP, Kashyap ML. Interchange of apolipoproteins between chylomicrons and high density lipoproteins during alimentary lipemia in man. Journal of Clinical Investigation 52: 32–38, 1973 Imaizumi K, Fainaru M, Havel RJ. Composition of mesenteric lymph chylomicrons in the rat and alterations produced upon exposure to chylomicrons to blood serum and serum proteins. Journal of Lipid Research 19: 712–722, 1978 Janus ED, Nicoll AM, Turner PR, Magill P, Lewis B. Kinetic bases of the primary hyperlipidaemias: studies of apolipoprotein B turnover in genetically defined subjects. European Journal of Clinical Investigation 10: 161–174, 1980 Kane JP, Havel RJ. Disorders of the biogenesis and secretion of lipoproteins containing the B apolipoproteins. In Scriver et al. (Eds) The metabolic basis of inherited disease, 6th ed., Vol. 1, pp. 1139–1164, New York, McGraw-Hill, 1989 Kane JP, Hardman DA, Paulus HE. Heterogeneity of apolipoprotein B: isolation of a new species from human chylomicrons. Proceedings of the National Academy of Sciences of the United States of America 77: 2465–2469, 1980 Knott TJ, Rall SC, Innerarity TL, et al. Human apolipoprotein B: structure of carboxy-terminal domains, sites of gene expression and chromosomal localisation. Science 230: 37–43, 1985 Krebs EG, Beavo JA. Phosphorylation-dephosphorylation of enzymes. Annual Review of Biochemistry 48: 923–959, 1979 Mahley RW, Innerarity TL. Lipoprotein receptors and cholesterol homeostasis. Biochimica Biophysica Acta 737: 197–222, 1983 Mjos OD, Faergeman O, Hamilton RL, Havel RJ. Characterisation of remnants produced during the metabolism of triglyceride-rich lipoproteins of blood plasma and intestinal lymph in the rat. Journal of Clinical Investigation 56: 603–615, 1975 Myant NB, Mitropoulos KA. Cholesterol 7α hydroxylase. Journal of Lipid Research 18: 135–153, 1977 Nicoll A, Lewis B. Evaluation of the roles of lipoprotein lipase and hepatic lipase in lipoprotein metabolism: in vivo and in vitro studies in man. European Journal of Clinical Investigation 10: 487–495, 1980 Nilsson-Ehle P, Garfunkel AS, Schotz MC. Lipolytic enzymes and plasma lipoprotein metabolism. Annual Review of Biochemistry 49: 667–693, 1980 Norum KR, Bert T, Helgerud P, Drevon CA. Transport of cholesterol. Physiological Review 63: 1343–1397, 1983 Norum KR, Miller NE, Miller CJ. Familial lecithin: cholesterol acyltransferase deficiency. In Miller et al. (Eds) Clinical and metabolic aspects of high density lipoproteins, pp. 297–318, Elsevier, Amsterdam, 1984 Packard CJ, Munro A, Lorimer A, Gotto AM, Shepherd J. Metabolism of apolipoprotein B in large triglyceride-rich very low density lipoproteins of normal and hypertriglyceridemic subjects. Journal of Clinical Investigation 74: 2178–2192, 1984 Packard CJ, Shepherd J. Cholesterol 7α hydroxylase: involvement in hepatobiliary axis and regulation of plasma lipoprotein levels. In Fears & Sabine (Eds) Cholesterol 7α hyydroxylase, pp. 47–165, CRC Press, Boca Raton, Fla, 1986 Parker TS, McNamara DJ, Brown C, et al. Mevalonic acid in human plasma: relationship of concentration and circadean rhythm to cholesterol synthesis rates in man. Proceedings of the National Academy of Sciences of the United States of America 79: 3037–3041, 1982 Patsch JR, Prasad SS, Gotto AM, Bengttson-Olivecrona G. Postprandial lipemia. Journal of Clinical Investigation 74: 2017–2023, 1984 Schaefer EJ, Jenkins LL, Brewer HB. Human chylomicron apolipoprotein catabolism. Biochemical Biophysical Research Communications 80: 405–412, 1978 Schaefer EJ, Wetzel MG, Bengttson G, et al. Transfer of human lymph chylomicron constituents of other lipoprotein density gradients during in vitro lipolysis. Journal of Lipid Research 23: 1259–1273, 1982 Shepherd J, Packard CJ, Stewart JM, et al. Apolipoprotein A and B (Sf 100–400) metabolism during bezafibrate therapy in hypertriglyceridemic subjects. Journal of Clinical Investigation 74: 2164–2177, 1984 Simpson HS, Williamson CM, Pringle S, et al. Hypolipidaemic drugs and chylomicron metabolism. In Greten (Ed) Intestinal lipid and lipoprotein metabolism, pp. 194–201, Zuckschwerdt Verlag, Munchen, 1989 Tall AR, Green PHR, Glickman RM, Riley JW. Metabolic fate of chylomicron phospholipids and apoproteins in the rat. Journal of Clinical Investigation 64: 977–989, 1979 Tall AR, Small DS. Plasma high density lipoproteins. New England Journal of Medicine 299: 1232–1236, 1978 Windler E, Chao Y, Havel RJ. Regulation of the hepatic uptake of triglyceride-rich lipoproteins in the rat. Journal of Biological Chemistry 55: 8303–8307, 1980 Wu AL, Windmueller HG. Relative contributions by liver and intestine to individual plasma apolipoproteins in the rat. Journal of Biological Chemistry 254: 7316–7322, 1979 Zilversmit DB. Lipid transfer proteins. Journal of Lipid Research 25: 1563–1569, 1984