1Department of Endocrinology, Dokkyo University School of Medicine, Mibu, Tochigi 321-02, Japan
2Department of Biochemistry, Meikai University School of Dentistry, Sakado, Saitama 350-02, Japan
Tóm tắt
A significant induction of GTP cyclohydrolase I (GTPCH) mRNA was observed in lung, heart and kidney of rats treated with lipopolysaccharide (LPS; 10 mg/kg i.v.). GTPCH mRNA levels in liver were high even in untreated rats, and remained elevated after LPS treatment. Parallel induction of nitric oxide synthase (NOS) mRNA was observed in these tissues of LPS‐treated rats. Our results demonstrate induction of GTPCH mRNA after LPS treatment in vivo and provide molecular evidence for the increased GTPCH activity which may up‐regulate NOS activity in vivo.
