Lipids and lipoproteins in persons with Down's syndrome

Journal of Intellectual Disability Research - Tập 36 Số 4 - Trang 365-369 - 1992
S. M. Pueschel1, Wendy Y. Craig1, James E. Haddow1
1Child Development Center, Department of Pediatrics, Rhode Island Hospital, Brown University School of Medicine, Providence, Rhode Island, and The Foundation for Blood Research, Scarborough, Maine, USA

Tóm tắt

ABSTRACT. This study was designed to investigate whether the observed decreased prevalence of coronary artery disease in individuals with Down's syndrome may be explained by their serum lipid and lipoprotein profiles. Twentyseven persons with Down's syndrome and 23 non‐afiFected control individuals were enrolled in this study. Their fasting venous blood was analysed for total cholesterol, triglyceride, LDH cholesterol, HDL cholesterol, apo B and apo AI. The results revealed no significant differences between the study and control group with regard to total cholesterol, LDL cholesterol, apo B and the apo B:apo AI ratio. However, triglyceride levels were significantly increased, and serum HDL cholesterol, apo AI and HDL cholesterohtotal cholesterol ratio were significantly decreased in patients with Down's syndrome when compared with the control group. The latter observations are all associated with an increased risk for coronary artery disease. Therefore, it is concluded that the decreased prevalence of coronary artery disease in individuals with Down's syndrome carmot be explained by the lipid and lipoprotein levels observed in this study population.

Từ khóa


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Thông tin xuất bản

Journal of Intellectual Disability Research

Tập 36 Số 4

365-369

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