Lipid nanoparticles (SLN & NLC) for delivery of vitamin E: a comprehensive review

International Journal of Cosmetic Science - Tập 40 Số 2 - Trang 103-116 - 2018
Vivian Sáez1, Ingrid Dantas Luciano de Souza1, Cláudia R. E. Mansur1
1Institute of Macromolecules (IMA/UFRJ) Federal University of Rio de Janeiro Av. Horácio Macedo, 2030 Rio de Janeiro RJ 21941598 Brazil

Tóm tắt

AbstractThe antioxidative and photoprotective properties of vitamin E have caused it to be included as an active agent in various pharmaceutical and cosmetic products. However, its lipophilicity, chemical instability and poor skin penetration have limited the effectiveness of these formulations. For that reason, many attempts to include it in different drug delivery systems have been made. In recent decades, lipid nanoparticles have received special attention due to their advantages of compatibility with the skin, ability to enhance penetration of drugs in the stratum corneum, protection of the encapsulated substance against degradation induced by the external medium and control of drug release. This work reviews the current status of the encapsulation of vitamin E in lipid nanoparticles. We describe the most important methods for obtaining and characterizing lipid nanoparticles containing vitamin E (LNPVE), various techniques for the evaluation of vitamin E's properties after encapsulation, the mainin vitroandin vivostudies of the potential effectiveness or toxicity ofLNPVE, the formulations and stability studies of this delivery system, the commercial products based onLNPVEand the regulatory aspects related to lipid nanoparticles. Finally, we discuss the most relevant advantages of encapsulating vitamin E in such particles and critical aspects that still demand attention to enhance the potential of solid lipid nanoparticles to deliver vitamin E.

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