Lipid and carbohydrate metabolism in uraemia

European Journal of Clinical Investigation - Tập 9 Số 4 - Trang 285-291 - 1979
Per‐Ola Attman1, A. Gustafson1
1Departments of Medicine I and V, University of Göteborg, Göteborg, Sweden

Tóm tắt

Abstract.Lipid and carbohydrate metabolism variables were studied in twenty‐eight patients with chronic renal failure (mean GFR 7.7 ± 2.5 ml/min) and uraemic symptoms.71% of the patients had hypertriglyceridaemia (≥ 2.2 mmol/l). Total serum cholesterol was normal while VLDL cholesterol was high and α‐lipoprotein cholesterol was low. The fractional elimination rate of Intralipid was low and inversely correlated to serum triglyceride levels.Intravenous glucose tolerance was reduced with normal or slightly increased fasting blood glucose and insulin values before and during the test.Serum triglycerides were correlated to plasma insulin but not to residual renal function or serum urea levels.The cause of hypertriglyceridaemia and lowering of α‐Lp cholesterol is not unequivocally clear. Present evidence indicate that retarded catabolism of triglyceride‐rich lipoproteins is important but accentuated release of triglyceride‐rich lipoproteins may have occurred in a number of cases. The commonly used treatment with β‐blocking agents for hypertension in chronic renal failure may accentuate certain of the metabolic responses in uraemia.

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Tài liệu tham khảo

10.1056/NEJM196807252790403

10.1097/00005792-197309000-00009

10.1111/j.1365-2362.1976.tb00507.x

Lindberg W., Høyde‐ og vektundersøkelser hos voksne men og kvinner. Forslag till nye norske høyd‐ og vektnormer., Tidsskr Nor Laegeforen, 76, 361

10.3109/00365597809179980

10.3109/00365515909060438

Carlson L.A., 1959, Determination of serum glycerides, Acta Soc Med Upsalien, 64, 208

10.1016/S0021-9258(18)70226-3

Friedberg S.J., The dynamics of plasma free fatty acid metabolism during exercise., J Lipid Res, 4, 34, 10.1016/S0022-2275(20)40362-1

10.3109/00365515609049272

Burstein M., 1959, Nouvelle méthode de séparation et de dosage des lipoprotéines de faible densité, Ann Biol Clin, 17, 23

10.1161/01.CIR.46.4.709

10.3109/00365517209080242

10.3109/00365517409061822

10.1111/j.0954-6820.1961.tb17091.x

10.1016/0009-8981(75)90383-6

Holm G., 1977, Studies on the metabolic effects of physical exercise

10.3109/00365517609055241

Blohmé G., 1974, Intravenous glucose tolerance and early insulin response. Studies on a random sample of women aged 50 and patients with diabetes mellitus, Acta Med Scand Suppl., 566, 26, 10.1111/j.0954-6820.1974.tb19166.x

10.3109/00365517509095749

10.3109/00365517709091492

10.1007/BF01479898

Bagdade J., 1976, Effects of chronic uremia, hemodialysis and renal transplantation on plasma lipids and lipoproteins in man, J Lab Clin Med, 87, 37

Ibels L.S., 1976, Plasma postheparin lipolytic activity and triglyceride clearance in uremic and hemodialysis patients and renal allograft recipients, J Lab Clin Med, 87, 648

10.1056/NEJM197712222972502

10.1111/j.0954-6820.1976.tb08270.x

Attman P.‐O., 1978, Dietary treatment in uremia

10.1152/jappl.1975.39.6.1022

Bagdade J.D., 1978, Hyperlipidemia in renal failure. Studies of plasma lipoproteins, hepatic triglyceride production and tissue lipoprotein lipase in a chronically uremic rat model, J Lab Clin Med, 91, 176

10.7326/0003-4819-85-1-29

10.1016/0026-0495(77)90009-9

10.1056/NEJM197706232962504

Wiklund O., 1978, High Density Lipoproteins and Atherosclerosis, 127

Reaven G.M., 1974, Insulin and glucose metabolism in renal insufficiency, Kidney Int, 6, 63

Westervelt F.B., 1969, Insulin effect in uremia, J Lab Clin Med, 74, 79

Lutz W., 1975, Studies on formation of complexes of insulin with basic peptides isolated from the plasma or uremic patients, Acta Med Pol, 16, 159

Amend W.J.C., 1975, The influence of serum calcium and parathyroid hormone upon glucose metabolism in uremia, J Lab Clin Med, 86, 435

Segura R., 1976, The Kidney in Systemic Disease, 159

10.1136/bmj.2.6087.601

10.1016/0026-0495(76)90014-7

McCosh E.J., 1975, Hypertriglyceridemia in patients with chronic renal insufficiency, Am J Clin Nutr, 28, 1036, 10.1093/ajcn/28.9.1036

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European Journal of Clinical Investigation

Tập 9 Số 4

285-291

Thông tin tác giả