Lipid Droplets: A New Player in Colorectal Cancer Stem Cells Unveiled by Spectroscopic Imaging

Jemal, 2006, Cancer statistics, 2006, CA Cancer J Clin, 56, 106, 10.3322/canjclin.56.2.106

Schwitalla, 2013, Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties, Cell, 152, 25, 10.1016/j.cell.2012.12.012

Barker, 2007, Identification of stem cells in small intestine and colon by marker gene Lgr5, Nature, 449, 1003, 10.1038/nature06196

Sneddon, 2007, Location, location, location: The cancer stem cell niche, Cell Stem Cell, 1, 607, 10.1016/j.stem.2007.11.009

Visvader, 2011, Cells of origin in cancer, Nature, 469, 314, 10.1038/nature09781

Vermeulen, 2010, Wnt activity defines colon cancer stem cells and is regulated by the microenvironment, Nat Cell Biol, 12, 468, 10.1038/ncb2048

Prasetyanti, 2013, Regulation of stem cell self-renewal and differentiation by Wnt and Notch are conserved throughout the adenoma-carcinoma sequence in the colon, Mol Cancer, 12, 10.1186/1476-4598-12-126

Dieter, 2011, Distinct types of tumor-initiating cells form human colon cancer tumors and metastases, Cell Stem Cell, 9, 357, 10.1016/j.stem.2011.08.010

Todaro, 2010, Colon cancer stem cells: Promise of targeted therapy, Gastroenterology, 138, 2151, 10.1053/j.gastro.2009.12.063

Todaro, 2007, Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4, Cell Stem Cell, 1, 389, 10.1016/j.stem.2007.08.001

Clarke, 2006, Stem cells and cancer: Two faces of eve, Cell, 124, 1111, 10.1016/j.cell.2006.03.011

Lathia, 2011, Seeing is believing: Are cancer stem cells the Loch Ness monster of tumor biology?, Stem Cell Rev Rep, 7, 227, 10.1007/s12015-010-9194-6

Shackleton, 2009, Heterogeneity in cancer: Cancer stem cells versus clonal evolution, Cell, 138, 822, 10.1016/j.cell.2009.08.017

Medema, 2013, Cancer stem cells: The challenges ahead, Nat Cell Biol, 15, 338, 10.1038/ncb2717

Clarke, 2006, Cancer stem cells—Perspectives on current status and future directions: AACR Workshop on cancer stem cells, Cancer Res, 66, 9339, 10.1158/0008-5472.CAN-06-3126

Ladman, 1988, Cell contacts and surface-features of 3 murine tumors grown as multicellular spheroids, Eur J Cell Biol, 45, 224

O'Brien, 2007, A human colon cancer cell capable of initiating tumour growth in immunodeficient mice, Nature, 445, 106, 10.1038/nature05372

Ricci-Vitiani, 2007, Identification and expansion of human colon-cancer-initiating cells, Nature, 445, 111, 10.1038/nature05384

Dalerba, 2007, Phenotypic characterization of human colorectal cancer stem cells, Proc Natl Acad Sci USA, 104, 10158, 10.1073/pnas.0703478104

Glazer, 2012, Musashi1: An RBP with versatile functions in normal and cancer stem cells, Front Biosci (Landmark Ed), 17, 54, 10.2741/3915

Schepers, 2012, Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas, Science, 337, 730, 10.1126/science.1224676

De Angelis, 2011, Nanoscale chemical mapping using three-dimensional adiabatic compression of surface plasmon polaritons, Nat Nanotechnol, 5, 67, 10.1038/nnano.2009.348

De Angelis, 2011, Breaking the diffusion limit with super-hydrophobic delivery of molecules to plasmonic nanofocusing SERS structures, Nat Photon, 5, 683, 10.1038/nphoton.2011.222

Cottat, 2013, Localized surface plasmon resonance (LSPR) biosensor for the protein detection, Plasmonics, 8, 699, 10.1007/s11468-012-9460-3

Das, 2010, Monitoring human leukocyte antigen class I molecules by micro-Raman spectroscopy at single-cell level, J Biomed Opt, 15, 027007, 10.1117/1.3368687

Uzunbajakava, 2003, Nonresonant confocal Raman imaging of DNA and protein distribution in apoptotic cells, Biophys J, 84, 3968, 10.1016/S0006-3495(03)75124-8

Matthaeus, 2008, New ways of imaging uptake and intracellular fate of liposomal drug carrier systems inside individual cells, based on Raman microscopy, Mol Pharm, 5, 287, 10.1021/mp7001158

Matthaus, 2007, Label-free detection of mitochondrial distribution in cells by nonresonant Raman microspectroscopy, Biophys J, 93, 668, 10.1529/biophysj.106.102061

Manen, 2005, Single-cell Raman and fluorescence microscopy reveal the association of lipid bodies with phagosomes in leukocytes, Proc Natl Acad Sci USA, 102, 10159, 10.1073/pnas.0502746102

Freudiger, 2008, Label-free biomedical imaging with high sensitivity by stimulated Raman scattering microscopy, Science, 322, 1857, 10.1126/science.1165758

Listenberger, 2007, Current Protocols in Cell Biology/Editorial Board, 2

Spandl, 2009, Live cell multicolor imaging of lipid droplets with a new dye, LD540, Traffic, 10, 1579, 10.1111/j.1600-0854.2009.00980.x

Hu, 2009, ELDA: Extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays, J Immunol Methods, 347, 70, 10.1016/j.jim.2009.06.008

Chan, 2005, Raman spectroscopic analysis of biochemical changes in individual triglyceride-rich lipoproteins in the pre- and postprandial state, Anal Chem, 77, 5870, 10.1021/ac050692f

Wu, 2011, In vivo lipidomics using single-cell Raman spectroscopy, Proc Natl Acad Sci USA, 108, 3809, 10.1073/pnas.1009043108

Candeloro, 2013, Raman database of amino acids solutions: A critical study of extended multiplicative signal correction, Analyst, 138, 7331, 10.1039/c3an01665j

Martin, 2006, Lipid droplets: A unified view of a dynamic organelle, Nat Rev Mol Cell Biol, 7, 373, 10.1038/nrm1912

Goodman, 2009, Demonstrated and inferred metabolism associated with cytosolic lipid droplets, J Lipid Res, 50, 2148, 10.1194/jlr.R001446

Schneider, 2012, NIH Image to ImageJ: 25 years of image analysis, Nat Methods, 9, 671, 10.1038/nmeth.2089

Dees, 2001, Effect of mono-ethylhexyl phthalate on MA-10 Leydig tumor cells, Reprod Toxicol, 15, 171, 10.1016/S0890-6238(01)00110-1

Bozza, 2010, Lipid droplets in inflammation and cancer, Prostaglandins Leukot Essent Fatty Acids, 82, 243, 10.1016/j.plefa.2010.02.005

Farese, 2009, Lipid droplets finally get a little R-E-S-P-E-C-T, Cell, 139, 855, 10.1016/j.cell.2009.11.005

Accioly, 2008, Lipid bodies are reservoirs of cyclooxygenase-2 and sites of prostaglandin-E-2 synthesis in colon cancer cells, Cancer Res, 68, 1732, 10.1158/0008-5472.CAN-07-1999

Mutoh, 2009, Overexpression of low-density lipoprotein receptor and lipid accumulation in intestinal polyps in Min mice, Int J Cancer, 125, 2505, 10.1002/ijc.24667

Eberhart, 1994, Up-regulation of cyclooxygenase-2 gene-expression in human colorectal adenomas and adenocarcinomas, Gastroenterology, 107, 1183, 10.1016/0016-5085(94)90246-1

Kargman, 1995, Expression of prostaglandin G/H synthase-1 and synthase-2 protein in human colon-cancer, Cancer Res, 55, 2556

Sano, 1995, Expression of cyclooxygenase-1 and cyclooxygenase-2 in human colorectal-cancer, Cancer Res, 55, 3785

Fujimoto, 2001, Caevolin-2 is targeted to lipid droplets, a new “membrane domain” in the cell, J Cell Biol, 152, 1079, 10.1083/jcb.152.5.1079

Pol, 2001, A caveolin dominant negative mutant associates with lipid bodies and induces intracellular cholesterol imbalance, J Cell Biol, 152, 1057, 10.1083/jcb.152.5.1057

Yu, 2000, Phosphatidylinositide 3-kinase localizes to cytoplasmic lipid bodies in human polymorphonuclear leukocytes and other myeloid-derived cells, Blood, 95, 1078, 10.1182/blood.V95.3.1078.003k16_1078_1085

Matsubara, 2011, Identification of adipophilin as a potential plasma biomarker for colorectal cancer using label-free quantitative mass spectrometry and protein microarray, Cancer Epidemiol Biomarkers Prev, 20, 2195, 10.1158/1055-9965.EPI-11-0400

Thun, 2002, Nonsteroidal anti-inflammatory drugs as anticancer agents: Mechanistic, pharmacologic, and clinical issues, J Natl Cancer Inst, 94, 252, 10.1093/jnci/94.4.252

Thun, 2012, The role of aspirin in cancer prevention. Nature reviews, Clin Oncol, 9, 259

Ali, 2011, The utility of Aspirin in dukes C and high risk dukes B colorectal cancer - The ASCOLT study: Study protocol for a randomized controlled trial, Trials, 12, 261, 10.1186/1745-6215-12-261

Ito, 2014, Metabolic requirements for the maintenance of self-renewing stem cells, Nat Rev Mol Cell Biol, 15, 243, 10.1038/nrm3772

Sorrentino, 2014, Metabolic control of YAP and TAZ by the mevalonate pathway, Nat Cell Biol, 16, 357, 10.1038/ncb2936

Francescangeli, 2012, Proliferation state and polo-like kinase1 dependence of tumorigenic colon cancer cells, Stem Cells, 30, 1819, 10.1002/stem.1163

Santos, 2012, Lipid metabolism in cancer, FEBS J, 279, 2610, 10.1111/j.1742-4658.2012.08644.x

Ji, 2013, Rapid, label-free detection of brain tumors with stimulated raman scattering microscopy, Sci Transl Med, 5, 10.1126/scitranslmed.3005954

Saar, 2011, Coherent Raman scanning fiber endoscopy, Opt Lett, 36, 2396, 10.1364/OL.36.002396