Linkage analysis of a derived glucose phenotype in the Genetic Analysis Workshop 13 simulated data using a variety of Haseman-Elston based regression methods

Hasman JK, Elston RC: The investigation of linkage between a quantitative trait and a marker locus. Behav Genet. 1972, 2: 3-19. 10.1007/BF01066731. Elston RC, Buxbaum S, Jacobs KB, Olson JM: Haseman and Elston revisited. Genet Epidemiol. 2000, 19: 1-17. 10.1002/1098-2272(200007)19:1<1::AID-GEPI1>3.0.CO;2-E. Xu X, Weiss S, Xo X, Wei LJ: A unified Haseman-Elston method for testing linkage with quantitative traits. Am J Hum Genet. 2000, 67: 1025-1028. 10.1086/303081. Holmans P: Detecting gene-gene interactions using affected sib pair analysis with covariates. Hum Hered. 2002, 53: 92-102. 10.1159/000057987. Sham PC, Purcell S, Cherney SS, Abecasis GR: Powerful regression-based quantitative trait linkage analysis of general pedigrees. Am J Hum Genet. 2002, 71: 238-253. 10.1086/341560. Huber P: The behaviour of maximum likelihood estimates under non-standard conditions. In Proceedings of the Fifth Berkeley Symposium in Mathematical Statistics and Probability. 1967, Berkeley: University of California Press, 1: 221-233. White H: Maximum likelihood estimation of misspecified models. Econometrica. 1982, 50: 1-25. 10.2307/1912526. Stata Statistical Software. [http://www.stata.com]