Linear Motif Atlas for Phosphorylation-Dependent Signaling

Science Signaling - Tập 1 Số 35 - 2008
Martin L. Miller1,2, Lars Juhl Jensen3,2, Francesca Diella3, Claus Jørgensen4, Michele Tinti5, Lei Li6, Marilyn S. Hsiung4, Sirlester A. Parker7, Jennifer Bordeaux7, Thomas Sicheritz‐Pontén1, Marina Olhovsky4, Adrian Pasculescu4, Jes Alexander8, Stefan Knapp9, Nikolaj Blom1, Peer Bork10,2, Shawn Li6, Gianni Cesareni5, Tony Pawson4, Benjamin E. Turk7, Michael B. Yaffe8, Søren Brunak1,2, Rune Linding11,8,4
1Center for Biological Sequence Analysis, Technical University of Denmark, 2800, Lyngby, Denmark
2The Novo Nordisk Foundation Centre for Protein Research, University of Copenhagen, 2200 Copenhagen, Denmark.
3European Molecular Biology Laboratory, 69117 Heidelberg, Germany
4Samuel Lunenfeld Research Institute, Mount Sinai Hospital, M5G 1X5 Toronto, Ontario, Canada.
5University of Rome ‘Tor Vergata’, 00133 Rome, Italy
6University of Western Ontario, N6A 5C1 London, Ontario, Canada.
7Department of Pharmacology, Yale University School of Medicine, New Haven, 06520 CT, USA.
8Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, 021329 MA, USA.
9Structural Genomics Consortium, University of Oxford, OX3 7DQ Oxford, UK.
10Max-Delbrück-Centre for Molecular Medicine, 13092 Berlin, Germany.
11Cellular & Molecular Logic Team, The Institute of Cancer Research, SW3 6JB London, UK.

Tóm tắt

Created with both in vitro and in vivo data, NetPhorest is an atlas of consensus sequence motifs for 179 kinases and 104 phosphorylation-dependent binding domains and reveals new insight into phosphorylation-dependent signaling.

Từ khóa


Tài liệu tham khảo

10.1093/nar/gkg519

10.1093/nar/gkj149

10.1093/nar/gkj079

Yaffe M. B. , "Bits" and pieces. Sci. STKE 2006, pe28 (2006).

10.1038/nature05186

10.1016/j.febslet.2005.04.005

10.1093/bfgp/eln001

10.1073/pnas.0404720101

10.1016/j.cell.2006.09.026

10.1016/j.copbio.2007.07.005

10.1073/pnas.0608638104

10.1016/j.cell.2007.05.052

10.1093/nar/gkg584

10.1093/nar/gkg545

10.1074/jbc.M005497200

10.1038/nmeth708

10.1074/jbc.M311886200

10.1038/nbt0307-285

10.1093/nar/gkm977

10.1002/pmic.200300771

10.1093/bioinformatics/bth382

10.1093/nar/gki393

10.1186/1471-2105-7-163

10.1093/nar/gkm322

10.1126/science.1075762

10.1093/nar/gkm772

10.1093/nar/gkl961

10.1038/nature04177

10.1016/j.molcel.2006.06.001

10.1093/bioinformatics/16.5.412

10.1016/j.molcel.2004.11.021

10.1038/nbt1386

10.1074/mcp.M700312-MCP200

The data are available from the NetPhorest Web site (http://netphorest.info).

10.1023/A:1006960004440

10.1093/protein/12.1.3

10.1093/bioinformatics/btg036

10.1148/radiology.143.1.7063747

10.1038/nrm2203

10.1016/j.tibs.2007.06.004

10.1038/emboj.2008.8

10.1371/journal.pbio.0020014

10.1016/j.sbi.2007.08.007

10.1038/nmeth1048

10.1126/science.1140321

10.1038/nbt1308

10.1093/nar/gkm854

10.1038/msb4100012

10.1128/MCB.01491-06

10.1093/nar/gki198

10.1080/10635150701472164

10.1080/10635150390235520

10.1093/bioinformatics/btl158

10.1006/jmbi.1999.3310

10.1093/bioinformatics/16.8.699

10.1038/nrc1299

10.1093/nar/gkm902

10.1038/nmeth1005