Limbic Dysfunction in Schizophrenia and Mania

British Journal of Psychiatry - Tập 169 Số 4 - Trang 509-516 - 1996
A.H. Al-Mousawi1, N. Evans2, Klaus P. Ebmeier2, Dirk Roeda3, F. Chaloner3, G Ashcroft4
1Department of Psychological Medicine, University of Wales College of Medicine
2MRC Brain Metabolism Unit, Edinburgh
3Department of Bio-Medical Physics, University of Aberdeen
4University of Aberdeen

Tóm tắt

Background

Diagnostic classes (derived from catego) can be correlated with regional brain metabolism in patients with major psychiatric disorders.

Method

Seventeen patients with schizophrenia, 15 with mania, 10 with depression and 10 healthy volunteers were examined with positron emission tomography (PET) and 18F-labelled fluorodeoxyglucose, as a marker for glucose metabolism. The number of possible comparisons of regions of interest was reduced by principal-components analysis, and differences in factor scores were determined between diagnostic groups.

Results

Four independent factors, representing distributed brain systems, emerged: an anterior–posterior (1), a left–right temporal (2), a temporofrontal (3), and a mediofrontal (4) system, of which (1), (2) and (3) were abnormal in schizophrenia, (1) and (2) in mania, and (1) in depression.

Conclusions

Abnormal patterns of metabolism could be detected, in decreasing order, in schizophrenia, mania and depression. Some of these abnormalities are likely to be due to medication, but others will be associated with structural or functional abnormalities of the frontolimbic system in the diagnostic groups.

Từ khóa


Tài liệu tham khảo

10.1001/archpsyc.1992.01820120023005

10.1192/bjp.154.2.170

Cummings, 1984, Secondary mania with focal cerebrovascular lesions, American Journal of Psychiatry, 141, 1084, 10.1176/ajp.141.9.1084

10.1001/archpsyc.1986.01800020032005

Schneider, 1959, Clinical Psychopathology

10.1192/bjp.156.2.195

10.1001/archpsyc.1992.01820070016003

Wing, 1974, Measurement and Classification of Psychiatric Symptoms.

10.1016/0006-3223(93)90002-U

10.1016/0893-133X(89)90028-6

10.1001/archpsyc.1986.01800010038005

10.1056/NEJM199003223221201

10.1016/0925-4927(91)90003-9

10.1001/archpsyc.1987.01800240070010

10.1016/0165-0327(86)90036-4

Aquilonius, 1980, A Colour Atlas of The Human Brain Adapted to Computed Tomography.

10.1001/archpsyc.1985.01790310046006

10.1192/bjp.160.2.179

Davison, 1969, Current Problems in Neuropsychiatry, British Journal of Psychiatry Special Publication No. 4, 113

10.1001/archpsyc.1987.01800140021003

10.1002/ana.410150730

10.1001/archpsyc.1989.01810030049007

Suddath, 1989, Temporal lobe pathology in schizophrenia: a quantitative magnetic resonance imaging study, American Journal of Psychiatry, 146, 464, 10.1176/ajp.146.4.464

10.1159/000118834

10.1001/archpsyc.1991.01810290025003

DeLisi, 1985, Clinical correlates of decreased anteroposterior metabolic gradients in positron emission tomography of schizophrenia patients, American Journal of Psychiatry, 142, 78, 10.1176/ajp.142.1.78

10.1016/0165-0327(92)90032-2

10.1016/0010-440X(89)90123-5

10.1111/j.2044-8295.1970.tb01248.x

10.1038/305527a0

10.1016/0925-4927(90)90004-P

10.1001/archpsyc.1992.01820120054008

10.1001/archpsyc.1988.01800300019002

10.1001/archpsyc.1987.01800140028004

1993, SPSS for Windows: Advanced Statistics, Release 6.

10.1017/S003329170003806X

Siegel, 1993, Cortical–striatal–thalamic circuits and brain glucose metabolic activity in 70 unmedicated male schizophrenic patients, American Journal of Psychiatry, 150, 1325, 10.1176/ajp.150.9.1325