Limbic Dysfunction in Schizophrenia and Mania

British Journal of Psychiatry - Tập 169 Số 4 - Trang 509-516 - 1996
A.H. Al-Mousawi1, N. Evans2, Klaus P. Ebmeier2, Dirk Roeda3, F. Chaloner3, G Ashcroft4
1Department of Psychological Medicine, University of Wales College of Medicine
2MRC Brain Metabolism Unit, Edinburgh
3Department of Bio-Medical Physics, University of Aberdeen
4University of Aberdeen

Tóm tắt

Background

Diagnostic classes (derived from catego) can be correlated with regional brain metabolism in patients with major psychiatric disorders.

Method

Seventeen patients with schizophrenia, 15 with mania, 10 with depression and 10 healthy volunteers were examined with positron emission tomography (PET) and 18F-labelled fluorodeoxyglucose, as a marker for glucose metabolism. The number of possible comparisons of regions of interest was reduced by principal-components analysis, and differences in factor scores were determined between diagnostic groups.

Results

Four independent factors, representing distributed brain systems, emerged: an anterior–posterior (1), a left–right temporal (2), a temporofrontal (3), and a mediofrontal (4) system, of which (1), (2) and (3) were abnormal in schizophrenia, (1) and (2) in mania, and (1) in depression.

Conclusions

Abnormal patterns of metabolism could be detected, in decreasing order, in schizophrenia, mania and depression. Some of these abnormalities are likely to be due to medication, but others will be associated with structural or functional abnormalities of the frontolimbic system in the diagnostic groups.

Từ khóa


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Thông tin xuất bản

British Journal of Psychiatry

Tập 169 Số 4

509-516

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